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DFN-15 Dose 1 — Competitive Intelligence Brief
phase 2
5-HT7 receptor antagonist
5-HT7 receptor
Psychiatry/Neurology
Small molecule
Live · refreshed every 30 min
Target snapshot
DFN-15 Dose 1 (DFN-15 Dose 1) — Dr. Reddy's Laboratories Limited. DFN-15 is a selective serotonin 5-HT7 receptor antagonist designed to modulate serotonergic neurotransmission.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| DFN-15 Dose 1 TARGET | DFN-15 Dose 1 | Dr. Reddy's Laboratories Limited | phase 2 | 5-HT7 receptor antagonist | 5-HT7 receptor | |
| Latuda (Lurasidone) | Latuda (Lurasidone) | Massachusetts General Hospital | marketed | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT7 receptor | |
| Latuda© | Latuda© | University of North Carolina, Chapel Hill | marketed | Atypical antipsychotic | Dopamine D2 receptor, serotonin 5-HT7 receptor, serotonin 5-HT1A receptor | |
| NRX-101 Oral Capsule | NRX-101 Oral Capsule | NeuroRx, Inc. | phase 3 | Fixed-dose combination (NMDA receptor modulator + atypical antipsychotic) | NMDA receptor (d-cycloserine component); dopamine D2 receptor and serotonin 5-HT7 receptor (lurasidone component) | |
| Vortioxetine tablets | Vortioxetine tablets | Takeda | phase 3 | Serotonin modulator and stimulator | 5-HT3 receptor, 5-HT1A receptor, 5-HT7 receptor, norepinephrine transporter | |
| OPC-34712 | OPC-34712 | Otsuka Pharmaceutical Development & Commercialization, Inc. | phase 3 | 5-HT7 receptor antagonist | 5-HT7 receptor | |
| Phase 1: Aripiprazole | Phase 1: Aripiprazole | Shanghai Mental Health Center | phase 3 | Atypical antipsychotic | Dopamine D2/D3 receptor (partial agonist); serotonin 5-HT1A and 5-HT7 receptors |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (5-HT7 receptor antagonist class)
- Otsuka Pharmaceutical Development & Commercialization, Inc. · 2 drugs in this class
- Dr. Reddy's Laboratories Limited · 1 drug in this class
- Eli Lilly and Company · 1 drug in this class
- Neumora Therapeutics, Inc. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). DFN-15 Dose 1 — Competitive Intelligence Brief. https://druglandscape.com/ci/dfn-15-dose-1. Accessed 2026-06-10.
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