depakine chrono — Competitive Intelligence Brief

depakine chrono (depakine chrono) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Anticonvulsant / Mood stabilizer. Area: Neurology / Psychiatry.

marketed Anticonvulsant / Mood stabilizer GABA metabolism; histone deacetylase Neurology / Psychiatry Small molecule

Target snapshot

depakine chrono (depakine chrono) — Sanofi. Depakine Chrono (valproic acid) increases brain GABA levels and inhibits histone deacetylase, enhancing inhibitory neurotransmission and gene expression.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
depakine chrono TARGET	depakine chrono	Sanofi	marketed	Anticonvulsant / Mood stabilizer	GABA metabolism; histone deacetylase
Depakote (divalproate)	Depakote (divalproate)	Korea Otsuka Pharmaceutical Co., Ltd.	marketed	Anticonvulsant / Mood stabilizer	GABA metabolism; histone deacetylase inhibition
Lamictal TM	Lamictal TM	Central Mental Clinic for Outpatients of Baku City	marketed	Anticonvulsant / Mood stabilizer	Voltage-gated sodium channels; glutamate release inhibition
Lamotrigine Generic "A"	Lamotrigine Generic "A"	University of Cincinnati	marketed	Anticonvulsant / Mood stabilizer	Voltage-gated sodium channels; glutamate release inhibition
Divalproex (DIV) ER	Divalproex (DIV) ER	The University of Texas Health Science Center at San Antonio	marketed	Anticonvulsant / Mood stabilizer	GABA synthesis enhancement; histone deacetylase inhibition
valproate microgranules	valproate microgranules	Sanofi	marketed	Anticonvulsant / Mood stabilizer	Histone deacetylase; GABA metabolism
Lamotrigine tablet	Lamotrigine tablet	Dhaka Medical College	marketed	Anticonvulsant / Mood stabilizer	Voltage-gated sodium channels; glutamate release inhibition

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Anticonvulsant / Mood stabilizer class)

1. University of Maryland, Baltimore · 4 drugs in this class
2. Sanofi · 2 drugs in this class
3. University of Cincinnati · 2 drugs in this class
4. Mario Negri Institute for Pharmacological Research · 1 drug in this class
5. Central Mental Clinic for Outpatients of Baku City · 1 drug in this class
6. The University of Texas Health Science Center at San Antonio · 1 drug in this class
7. University Hospitals Cleveland Medical Center · 1 drug in this class
8. Dhaka Medical College · 1 drug in this class
9. Korea Otsuka Pharmaceutical Co., Ltd. · 1 drug in this class