Who are DE-117's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Netarsudil Ophthalmic, Eybelis ophthalmic solution 0.002%, DE-117B Eye Drops, DE-117 Ophthalmic Solution.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

DE-117 — Competitive Intelligence Brief

DE-117 (DE-117) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Rho kinase (ROCK) inhibitor. Area: Ophthalmology.

phase 3 Rho kinase (ROCK) inhibitor ROCK1/ROCK2 Ophthalmology Small molecule Live · refreshed every 30 min

Target snapshot

DE-117 (DE-117) — Santen Inc.. DE-117 is a selective rho kinase (ROCK) inhibitor that reduces intraocular pressure by improving aqueous humor outflow through the trabecular meshwork and Schlemm's canal.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
DE-117 TARGET	DE-117	Santen Inc.	phase 3	Rho kinase (ROCK) inhibitor	ROCK1/ROCK2
Netarsudil Ophthalmic	Netarsudil Ophthalmic	University of the Incarnate Word	marketed	Rho kinase inhibitor	ROCK1/ROCK2, norepinephrine transporter
Eybelis ophthalmic solution 0.002%	Eybelis ophthalmic solution 0.002%	Santen Pharmaceutical Asia Pte. Ltd.	marketed	Rho kinase (ROCK) inhibitor	ROCK1/ROCK2
DE-117B Eye Drops	DE-117B Eye Drops	Santen Pharmaceutical Co., Ltd.	phase 3	Rho kinase (ROCK) inhibitor	ROCK1/ROCK2
DE-117 Ophthalmic Solution	DE-117 Ophthalmic Solution	Santen Inc.	phase 3	Rho kinase (ROCK) inhibitor	ROCK1/ROCK2

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Rho kinase (ROCK) inhibitor class)

Santen Inc. · 3 drugs in this class
Santen Pharmaceutical Asia Pte. Ltd. · 1 drug in this class
Santen Pharmaceutical Co., Ltd. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). DE-117 — Competitive Intelligence Brief. https://druglandscape.com/ci/de-117. Accessed 2026-05-13.

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