Who are CycloSPORINE Ophthalmic's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Sandimmune, CYCLOSPORINE, Change from Prograf to Envarsus XR, Ciclosporin soft capsules, Arm 1 Everolimus/Reduced dose tacrolimus, LUPKYNIS.

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Last reviewed 2026-05-16 · How we verify

CycloSPORINE Ophthalmic — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

CycloSPORINE Ophthalmic (CycloSPORINE Ophthalmic) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Calcineurin inhibitor. Area: Ophthalmology.

marketed Calcineurin inhibitor Calcineurin Ophthalmology Small molecule Live · refreshed every 30 min

Target snapshot

CycloSPORINE Ophthalmic (CycloSPORINE Ophthalmic) — Université de Sherbrooke. Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
CycloSPORINE Ophthalmic TARGET	CycloSPORINE Ophthalmic	Université de Sherbrooke	marketed	Calcineurin inhibitor	Calcineurin
Sandimmune	cyclosporine	Novartis AG (originally Sandoz)	marketed	Calcineurin inhibitor (immunosuppressant)	Calcineurin subunit B type 1, Canalicular multispecific organic anion transporter 1, Canalicular multispecific organic anion transporter 2	1983-11-14
CYCLOSPORINE	CYCLOSPORINE		marketed	Calcineurin Inhibitor Immunosuppressant [EPC]	calcineurin	1983-01-01
Change from Prograf to Envarsus XR	Change from Prograf to Envarsus XR	Vanderbilt University Medical Center	marketed	Calcineurin inhibitor	Calcineurin (protein phosphatase 2B)
Ciclosporin soft capsules	Ciclosporin soft capsules	Chinese PLA General Hospital	marketed	Calcineurin inhibitor	Calcineurin (protein phosphatase 2B)
Arm 1 Everolimus/Reduced dose tacrolimus	Arm 1 Everolimus/Reduced dose tacrolimus	University of Toledo Health Science Campus	marketed	mTOR inhibitor + Calcineurin inhibitor combination	mTOR; Calcineurin (PP2B)
LUPKYNIS	LUPKYNIS	Aurinia Pharmaceuticals Inc.	marketed	Calcineurin inhibitor	Calcineurin (via cyclophilin binding)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-11-03 — Sandimmune · 8298568 · Formulation · US
2029-06-02 — Sandimmune · 9132071 · Formulation · US
2030-12-13 — Sandimmune · 8614178 · Formulation · US
2031-02-25 — Sandimmune · 8292129 · Formulation · US
2032-04-16 — Sandimmune · 8561859 · Formulation · US
2033-08-23 — Sandimmune · 8980839 · Formulation · US
2033-08-23 — Sandimmune · 10441630 · Formulation · US
2033-08-23 — Sandimmune · 9937225 · Formulation · US
2034-02-07 — Sandimmune · 9676525 · Formulation · US
2034-05-11 — Sandimmune · 9669974 · Formulation · US
2036-09-29 — Sandimmune · 12496326 · Method of Use · US
2037-02-28 — Sandimmune · 11951153 · Method of Use · US
2037-02-28 — Sandimmune · 10918694 · Formulation · US
2037-09-22 — Sandimmune · 10813976 · Formulation · US
2038-11-20 — Sandimmune · 11154513 · Formulation · US
2039-10-11 — Sandimmune · 11413323 · Method of Use · US
2042-04-01 — Sandimmune · 12059449 · Formulation · US

Sponsor landscape (Calcineurin inhibitor class)

Novartis · 4 drugs in this class
Astellas Pharma Inc · 4 drugs in this class
Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · 4 drugs in this class
University of Cincinnati · 3 drugs in this class
Allergan · 3 drugs in this class
Astellas Pharma China, Inc. · 3 drugs in this class
Novaliq GmbH · 3 drugs in this class
Hoffmann-La Roche · 3 drugs in this class
LEO Pharma · 3 drugs in this class
Santen SAS · 3 drugs in this class

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Cite this brief

Drug Landscape (2026). CycloSPORINE Ophthalmic — Competitive Intelligence Brief. https://druglandscape.com/ci/cyclosporine-ophthalmic. Accessed 2026-05-16.

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