Who are Comparator: ondansetron IV's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trintellix, ondansetron (Zofran), Ondansetron (ODT), Ondansetron orodispersible film once, Aprepitant plus Ondansetron, Venlafaxine XR + Mirtazapine.

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Last reviewed 2026-06-10 · How we verify

Comparator: ondansetron IV — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparator: ondansetron IV (Comparator: ondansetron IV) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT3 receptor antagonist. Area: Supportive Care / Antiemetic.

phase 3 5-HT3 receptor antagonist 5-HT3 receptor Supportive Care / Antiemetic Small molecule Live · refreshed every 30 min

Target snapshot

Comparator: ondansetron IV (Comparator: ondansetron IV) — Merck Sharp & Dohme LLC. Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Comparator: ondansetron IV TARGET	Comparator: ondansetron IV	Merck Sharp & Dohme LLC	phase 3	5-HT3 receptor antagonist	5-HT3 receptor
Trintellix	vortioxetine	Takeda	marketed	Serotonin modulator and stimulator (SMS); SSRI-like agent	Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor	2013-01-01
ondansetron (Zofran)	ondansetron (Zofran)	National Institute on Alcohol Abuse and Alcoholism (NIAAA)	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Ondansetron (ODT)	Ondansetron (ODT)	MonoSol Rx	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Ondansetron orodispersible film once	Ondansetron orodispersible film once	Chongqing University Cancer Hospital	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Aprepitant plus Ondansetron	Aprepitant plus Ondansetron	University of Pittsburgh	marketed	NK1 receptor antagonist + 5-HT3 receptor antagonist combination	NK1 receptor (aprepitant); 5-HT3 receptor (ondansetron)
Venlafaxine XR + Mirtazapine	Venlafaxine XR + Mirtazapine	National Institute of Mental Health (NIMH)	marketed	Antidepressant combination (SNRI + NaSSA)	Serotonin transporter, norepinephrine transporter, alpha-2 adrenergic receptors, 5-HT2 receptors, 5-HT3 receptors

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT3 receptor antagonist class)

Helsinn Healthcare SA · 4 drugs in this class
LG Life Sciences · 3 drugs in this class
University of Malaya · 2 drugs in this class
GlaxoSmithKline · 1 drug in this class
Hamad Medical Corporation · 1 drug in this class
Eye & ENT Hospital of Fudan University · 1 drug in this class
Instituto Mexicano del Seguro Social · 1 drug in this class
Chongqing University Cancer Hospital · 1 drug in this class
Merck Sharp & Dohme LLC · 1 drug in this class
MonoSol Rx · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Comparator: ondansetron IV — Competitive Intelligence Brief. https://druglandscape.com/ci/comparator-ondansetron-iv. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing