Who are Comparator: ezetimibe and simvastatin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): EZE/simvastatin, Ezetimibe and Simvastatin, Ezetimibe + Simvastatin, ezetimibe/simvastatin 10/40, Comparator: Placebo to ezetimibe/simvastatin.

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Last reviewed 2026-05-16 · How we verify

Comparator: ezetimibe and simvastatin — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparator: ezetimibe and simvastatin (Comparator: ezetimibe and simvastatin) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Combination lipid-lowering agent (ezetimibe + statin). Area: Cardiovascular.

phase 3 Combination lipid-lowering agent (ezetimibe + statin) NPC1L1 transporter (ezetimibe) and HMG-CoA reductase (simvastatin) Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Comparator: ezetimibe and simvastatin (Comparator: ezetimibe and simvastatin) — Organon and Co. This is a fixed-dose combination of ezetimibe (which blocks cholesterol absorption in the intestine) and simvastatin (which inhibits HMG-CoA reductase to reduce cholesterol synthesis), working synergistically to lower LDL cholesterol.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Comparator: ezetimibe and simvastatin TARGET	Comparator: ezetimibe and simvastatin	Organon and Co	phase 3	Combination lipid-lowering agent (ezetimibe + statin)	NPC1L1 transporter (ezetimibe) and HMG-CoA reductase (simvastatin)
EZE/simvastatin	EZE/simvastatin	Azienda Ospedaliero Universitaria di Sassari	marketed	Combination lipid-lowering agent (ezetimibe + statin)	NPC1L1 transporter (ezetimibe); HMG-CoA reductase (simvastatin)
Ezetimibe and Simvastatin	Ezetimibe and Simvastatin	University of Texas Southwestern Medical Center	marketed	Combination lipid-lowering agent (ezetimibe + statin)	NPC1L1 transporter (ezetimibe); HMG-CoA reductase (simvastatin)
Ezetimibe + Simvastatin	Ezetimibe + Simvastatin	Organon and Co	marketed	Combination lipid-lowering agent (ezetimibe + statin)	NPC1L1 transporter (ezetimibe); HMG-CoA reductase (simvastatin)
ezetimibe/simvastatin 10/40	ezetimibe/simvastatin 10/40	Organon and Co	phase 3	Combination lipid-lowering agent (ezetimibe + statin)	NPC1L1 transporter (ezetimibe); HMG-CoA reductase (simvastatin)
Comparator: Placebo to ezetimibe/simvastatin	Comparator: Placebo to ezetimibe/simvastatin	Organon and Co	phase 3	Combination lipid-lowering agent (ezetimibe + statin)	NPC1L1 transporter (ezetimibe); HMG-CoA reductase (simvastatin)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Combination lipid-lowering agent (ezetimibe + statin) class)

Organon and Co · 4 drugs in this class
Azienda Ospedaliero Universitaria di Sassari · 1 drug in this class
University of Texas Southwestern Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Comparator: ezetimibe and simvastatin — Competitive Intelligence Brief. https://druglandscape.com/ci/comparator-ezetimibe-and-simvastatin. Accessed 2026-05-16.

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