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CNTO 148 — Competitive Intelligence Brief
phase 3
TNF-α inhibitor (monoclonal antibody)
TNF-α (Tumor Necrosis Factor-alpha)
Immunology
Small molecule
Live · refreshed every 30 min
Target snapshot
CNTO 148 (CNTO 148) — Janssen Pharmaceutical K.K.. CNTO 148 is a monoclonal antibody that blocks tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling in immune-mediated diseases.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| CNTO 148 TARGET | CNTO 148 | Janssen Pharmaceutical K.K. | phase 3 | TNF-α inhibitor (monoclonal antibody) | TNF-α (Tumor Necrosis Factor-alpha) | |
| Infliximab and immunosuppressives | Infliximab and immunosuppressives | Children's Hospital of Fudan University | marketed | TNF-α inhibitor (monoclonal antibody) + immunosuppressive agents | TNF-α receptor (via infliximab); multiple targets depending on co-administered immunosuppressive | |
| SB5 | SB5 | Samsung Bioepis Co., Ltd. | marketed | TNF-α inhibitor (monoclonal antibody); biosimilar | TNF-α (tumor necrosis factor-alpha) | |
| Adalimumab and its biosimilars | Adalimumab and its biosimilars | Hanyang University Seoul Hospital | marketed | TNF-α inhibitor (monoclonal antibody) | TNF-α (tumor necrosis factor-alpha) | |
| Adalimumab (ADA) | Adalimumab (ADA) | JHSPH Center for Clinical Trials | marketed | TNF-α inhibitor (monoclonal antibody) | TNF-α (tumor necrosis factor-alpha) | |
| Adalimumab (Humira) | Adalimumab (Humira) | Tufts Medical Center | marketed | TNF-α inhibitor (monoclonal antibody) | TNF-α (Tumor Necrosis Factor-alpha) | |
| Infliximab biosimilar | Infliximab biosimilar | Hanyang University Seoul Hospital | marketed | TNF-α inhibitor (monoclonal antibody) | TNF-α (tumor necrosis factor-alpha) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (TNF-α inhibitor (monoclonal antibody) class)
- Merck Sharp & Dohme LLC · 3 drugs in this class
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · 2 drugs in this class
- Hanyang University Seoul Hospital · 2 drugs in this class
- Biocad · 1 drug in this class
- Children's Memorial Health Institute, Poland · 1 drug in this class
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · 1 drug in this class
- Centocor, Inc. · 1 drug in this class
- Hikma Pharmaceuticals LLC · 1 drug in this class
- Hospital de Manises · 1 drug in this class
- Celltrion · 1 drug in this class
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- CNTO 148 CI watch — RSS
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- Whole TNF-α inhibitor (monoclonal antibody) class — RSS
Cite this brief
Drug Landscape (2026). CNTO 148 — Competitive Intelligence Brief. https://druglandscape.com/ci/cnto-148. Accessed 2026-05-13.
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