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Clozaril — Competitive Intelligence Brief

Clozaril (CLOZAPINE) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Atypical Antipsychotic [EPC]. Area: Neuroscience.

marketed Atypical Antipsychotic [EPC] D2, 5-HT2A Neuroscience Small molecule Live · refreshed every 30 min

Target snapshot

Clozaril (CLOZAPINE) — Jazz Pharmaceuticals. Clozapine's efficacy in schizophrenia may be due to its antagonism of D2 and 5-HT2A receptors.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Clozaril TARGET CLOZAPINE Jazz Pharmaceuticals marketed Atypical Antipsychotic [EPC] D2, 5-HT2A 1989-01-01
SAMIDORPHAN L-MALATE SAMIDORPHAN L-MALATE marketed Atypical Antipsychotic [EPC] dopamine and serotonin type 2 (5HT2) receptors, opioid receptors 2021-01-01
Lybalvi SAMIDORPHAN Alkermes Inc marketed Atypical Antipsychotic [EPC] Mu-type opioid receptor 2021-01-01
Caplyta LUMATEPERONE Intra-Cellular marketed Atypical Antipsychotic [EPC] 5-hydroxytryptamine receptor 2A 2019-01-01
Nuplazid PIMAVANSERIN Acadia Pharms Inc marketed Atypical Antipsychotic 5-hydroxytryptamine receptor 2A 2016-01-01
Vraylar CARIPRAZINE AbbVie marketed Atypical Antipsychotic [EPC] D(3) dopamine receptor 2015-01-01
Rexulti BREXPIPRAZOLE Otsuka marketed Atypical Antipsychotic [EPC] D(2) dopamine receptor 2015-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

Sponsor landscape (Atypical Antipsychotic [EPC] class)

  1. · 2 drugs in this class
  2. AbbVie · 1 drug in this class
  3. Alkermes Inc · 1 drug in this class
  4. Eli Lilly · 1 drug in this class
  5. Hisamitsu · 1 drug in this class
  6. Intra-Cellular · 1 drug in this class
  7. Jazz Pharmaceuticals · 1 drug in this class
  8. Johnson & Johnson (Janssen) · 1 drug in this class
  9. Otsuka · 1 drug in this class
  10. Vanda Pharms Inc · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Clozaril — Competitive Intelligence Brief. https://druglandscape.com/ci/clozapine. Accessed 2026-05-13.

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