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Cladribine Pill — Competitive Intelligence Brief
phase 3
Purine nucleoside analog
Ribonucleotide reductase; DNA incorporation
Immunology; Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Cladribine Pill (Cladribine Pill) — Haukeland University Hospital. Cladribine is a purine nucleoside analog that inhibits ribonucleotide reductase and gets incorporated into DNA, leading to selective depletion of lymphocytes.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Cladribine Pill TARGET | Cladribine Pill | Haukeland University Hospital | phase 3 | Purine nucleoside analog | Ribonucleotide reductase; DNA incorporation | |
| Gemzar | Gemcitabine Hydrochloride | Accord Hlthcare | marketed | Nucleoside metabolic inhibitor | Ribonucleotide reductase; DNA incorporation | 1996-01-01 |
| Cladribine Tablets | Cladribine Tablets | Keith Edwards, M.D. | marketed | Purine nucleoside analog | Ribonucleotide reductase; DNA incorporation | |
| Gemcitabine Injectable Product | Gemcitabine Injectable Product | Henan Cancer Hospital | marketed | Nucleoside analog antimetabolite | Ribonucleotide reductase; DNA incorporation | |
| Gemcitabine monotherapy | Gemcitabine monotherapy | AstraZeneca | phase 3 | Nucleoside analog; antimetabolite | Ribonucleotide reductase; DNA incorporation | |
| Gemcitabine Hydrochloride Injection | Gemcitabine Hydrochloride Injection | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | phase 3 | Nucleoside analog; antimetabolite | Ribonucleotide reductase; DNA incorporation | |
| Cladribine (CLAD) | Cladribine (CLAD) | M.D. Anderson Cancer Center | marketed | Purine nucleoside analog | DNA (via deoxyadenosine analog incorporation) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
- — Gemzar · 12403086 · Formulation · US
- — Gemzar · 8679094 · Formulation · US
- — Gemzar · 9241948 · Formulation · US
- — Gemzar · 10729823 · Formulation · US
- — Gemzar · 12447241 · Formulation · US
Sponsor landscape (Purine nucleoside analog class)
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany · 2 drugs in this class
- Haukeland University Hospital · 1 drug in this class
- Keith Edwards, M.D. · 1 drug in this class
- M.D. Anderson Cancer Center · 1 drug in this class
- Nanfang Hospital, Southern Medical University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Cladribine Pill — Competitive Intelligence Brief. https://druglandscape.com/ci/cladribine-pill. Accessed 2026-06-10.
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing