Who are CE-224,535's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Brukinsa, Calquence, (G) BQ-L14, Acalabrutinib capsule, MGd, Ibrutinib Oral Capsule.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

CE-224,535 — Competitive Intelligence Brief

CE-224,535 (CE-224,535) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: BTK inhibitor. Area: Oncology.

phase 2 BTK inhibitor BTK Oncology Small molecule Live · refreshed every 30 min

Target snapshot

CE-224,535 (CE-224,535) — Pfizer. CE-224,535 is a small molecule inhibitor of the Bruton's tyrosine kinase (BTK) enzyme.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
CE-224,535 TARGET	CE-224,535	Pfizer	phase 2	BTK inhibitor	BTK
Brukinsa	BGB-3111	Beigene Usa Inc	marketed	Kinase Inhibitor [EPC]	Tyrosine-protein kinase BTK	2019-01-01
Calquence	ACALABRUTINIB	AstraZeneca	marketed	Kinase Inhibitor [EPC]	Tyrosine-protein kinase BTK	2017-01-01
(G) BQ-L14	(G) BQ-L14	National Taiwan University Hospital	marketed	BTK inhibitor	BTK
Acalabrutinib capsule	Acalabrutinib capsule	AstraZeneca	marketed	Bruton's tyrosine kinase (BTK) inhibitor	BTK (Bruton's tyrosine kinase)
MGd	MGd	Pharmacyclics LLC.	marketed	Bruton's tyrosine kinase (BTK) inhibitor	BTK (Bruton's tyrosine kinase)
Ibrutinib Oral Capsule	Ibrutinib Oral Capsule	Pharmacyclics LLC.	phase 3	Bruton's tyrosine kinase (BTK) inhibitor	BTK (Bruton's tyrosine kinase)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2034-04-22 — Brukinsa · 10570139 · US
2034-04-22 — Brukinsa · 11142528 · US
2034-04-22 — Brukinsa · 9447106 · US
2037-08-15 — Brukinsa · 11591340 · US
2037-08-15 — Brukinsa · 10927117 · US

Sponsor landscape (BTK inhibitor class)

Acerta Pharma BV · 4 drugs in this class
AstraZeneca · 4 drugs in this class
AbbVie · 2 drugs in this class
Eli Lilly and Company · 1 drug in this class
Fuji Yakuhin Co., Ltd. · 1 drug in this class
Genzyme, a Sanofi Company · 1 drug in this class
GlaxoSmithKline · 1 drug in this class
Janssen Research & Development, LLC · 1 drug in this class
National Taiwan University Hospital · 1 drug in this class
Pfizer · 1 drug in this class

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Cite this brief

Drug Landscape (2026). CE-224,535 — Competitive Intelligence Brief. https://druglandscape.com/ci/ce-224-535. Accessed 2026-05-14.

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