CC-220 — Competitive Intelligence Brief

CC-220 (CC-220) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: cereblon modulator. Area: Immunology.

phase 2 cereblon modulator cereblon Immunology Small molecule

Target snapshot

CC-220 (CC-220) — Celgene. CC-220 is a small molecule that modulates the activity of cereblon, an E3 ubiquitin ligase, leading to the degradation of specific proteins involved in inflammation and immune responses.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
CC-220 TARGET	CC-220	Celgene	phase 2	cereblon modulator	cereblon
Viekira Pak (Copackaged)	DASABUVIR	AbbVie	marketed	Hepatitis C Virus Non-Nucleoside NS5B Palm Polymerase Inhibitor	Protein cereblon	2014-01-01
Pomalyst	pomalidomide	Bristol-Myers Squibb	marketed	Thalidomide Analog [EPC]	Protein cereblon	2013-01-01
Revlimid	lenalidomide	Bristol-Myers Squibb	marketed	Thalidomide analogue	Cereblon (component of cullin ring E3 ubiquitin ligase enzyme complex)	2005-01-01
POMA	POMA	Bristol	marketed		Protein cereblon, Cereblon isoform 4
Drug: Carfilzomib + Lenalidomide + Dexamethasone	Drug: Carfilzomib + Lenalidomide + Dexamethasone	Amgen	marketed	Proteasome inhibitor + Immunomodulatory agent + Corticosteroid combination	20S proteasome (carfilzomib); cereblon/CRBN (lenalidomide); glucocorticoid receptor (dexamethasone)
Lenali	Lenali	Singapore General Hospital	marketed		Bromodomain-containing protein 4, Protein cereblon, Tumor necrosis factor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-09-17 — Viekira Pak (Copackaged) · 8501238 · US
• 2028-11-09 — Viekira Pak (Copackaged) · 9139536 · US
• 2029-05-17 — Viekira Pak (Copackaged) · 8188104 · US
• 2029-09-10 — Viekira Pak (Copackaged) · 8642538 · US
• 2030-06-10 — Viekira Pak (Copackaged) · 9006387 · US
• 2031-04-10 — Viekira Pak (Copackaged) · 8420596 · US
• 2031-04-10 — Viekira Pak (Copackaged) · 9044480 · US
• 2031-06-09 — Viekira Pak (Copackaged) · 8686026 · US
• 2032-04-13 — Viekira Pak (Copackaged) · 8691938 · US
• 2032-05-17 — Viekira Pak (Copackaged) · 10201541 · US
• 2032-05-17 — Viekira Pak (Copackaged) · 10201584 · US
• 2032-09-04 — Viekira Pak (Copackaged) · 8492386 · US
• 2032-09-04 — Viekira Pak (Copackaged) · 8680106 · US
• 2032-09-04 — Viekira Pak (Copackaged) · 8685984 · US
• 2032-09-04 — Viekira Pak (Copackaged) · 8466159 · US
• 2033-10-18 — Viekira Pak (Copackaged) · 10201542 · US
• 2033-10-18 — Viekira Pak (Copackaged) · 9629841 · US
• 2035-01-02 — Viekira Pak (Copackaged) · 9744170 · US
• 2035-01-02 — Viekira Pak (Copackaged) · 10105365 · US
• 2035-01-02 — Viekira Pak (Copackaged) · 9333204 · US

Sponsor landscape (cereblon modulator class)

1. Celgene · 1 drug in this class