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cardiac output changes with "ondansetron" — Competitive Intelligence Brief

cardiac output changes with "ondansetron" (cardiac output changes with "ondansetron") competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT3 receptor antagonist. Area: Oncology, Gastroenterology, Anesthesia.

marketed 5-HT3 receptor antagonist 5-HT3 receptor Oncology, Gastroenterology, Anesthesia Small molecule Live · refreshed every 30 min

Target snapshot

cardiac output changes with "ondansetron" (cardiac output changes with "ondansetron") — University Tunis El Manar. Ondansetron is a 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
cardiac output changes with "ondansetron" TARGET cardiac output changes with "ondansetron" University Tunis El Manar marketed 5-HT3 receptor antagonist 5-HT3 receptor
Trintellix vortioxetine Takeda marketed Serotonin modulator and stimulator (SMS); SSRI-like agent Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor 2013-01-01
Akynzeo solution Akynzeo solution Helsinn Healthcare SA marketed NK1 receptor antagonist / 5-HT3 receptor antagonist combination NK1 receptor (netupitant component); 5-HT3 receptor (palonosetron component)
Dexamethasone, Ondansetron, Aprepitant Dexamethasone, Ondansetron, Aprepitant Ottawa Hospital Research Institute marketed Antiemetic combination (corticosteroid + 5-HT3 antagonist + NK1 antagonist) Glucocorticoid receptor, 5-HT3 receptor, NK1 receptor
Palonosetron only Palonosetron only NYU Langone Health marketed 5-HT3 receptor antagonist 5-HT3 receptor
Palonosetron (Group P) Palonosetron (Group P) University of Malaya marketed 5-HT3 receptor antagonist 5-HT3 receptor
Ondansetron (ODT) Ondansetron (ODT) MonoSol Rx marketed 5-HT3 receptor antagonist 5-HT3 receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT3 receptor antagonist class)

  1. Helsinn Healthcare SA · 4 drugs in this class
  2. LG Life Sciences · 3 drugs in this class
  3. University of Malaya · 2 drugs in this class
  4. GlaxoSmithKline · 1 drug in this class
  5. Hamad Medical Corporation · 1 drug in this class
  6. Eye & ENT Hospital of Fudan University · 1 drug in this class
  7. Instituto Mexicano del Seguro Social · 1 drug in this class
  8. Chongqing University Cancer Hospital · 1 drug in this class
  9. Merck Sharp & Dohme LLC · 1 drug in this class
  10. MonoSol Rx · 1 drug in this class

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Cite this brief

Drug Landscape (2026). cardiac output changes with "ondansetron" — Competitive Intelligence Brief. https://druglandscape.com/ci/cardiac-output-changes-with-ondansetron. Accessed 2026-05-16.

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