Last reviewed · How we verify
cardiac output changes with "ondansetron" — Competitive Intelligence Brief
marketed
5-HT3 receptor antagonist
5-HT3 receptor
Oncology, Gastroenterology, Anesthesia
Small molecule
Live · refreshed every 30 min
Target snapshot
cardiac output changes with "ondansetron" (cardiac output changes with "ondansetron") — University Tunis El Manar. Ondansetron is a 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| cardiac output changes with "ondansetron" TARGET | cardiac output changes with "ondansetron" | University Tunis El Manar | marketed | 5-HT3 receptor antagonist | 5-HT3 receptor | |
| Trintellix | vortioxetine | Takeda | marketed | Serotonin modulator and stimulator (SMS); SSRI-like agent | Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor | 2013-01-01 |
| Akynzeo solution | Akynzeo solution | Helsinn Healthcare SA | marketed | NK1 receptor antagonist / 5-HT3 receptor antagonist combination | NK1 receptor (netupitant component); 5-HT3 receptor (palonosetron component) | |
| Dexamethasone, Ondansetron, Aprepitant | Dexamethasone, Ondansetron, Aprepitant | Ottawa Hospital Research Institute | marketed | Antiemetic combination (corticosteroid + 5-HT3 antagonist + NK1 antagonist) | Glucocorticoid receptor, 5-HT3 receptor, NK1 receptor | |
| Palonosetron only | Palonosetron only | NYU Langone Health | marketed | 5-HT3 receptor antagonist | 5-HT3 receptor | |
| Palonosetron (Group P) | Palonosetron (Group P) | University of Malaya | marketed | 5-HT3 receptor antagonist | 5-HT3 receptor | |
| Ondansetron (ODT) | Ondansetron (ODT) | MonoSol Rx | marketed | 5-HT3 receptor antagonist | 5-HT3 receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (5-HT3 receptor antagonist class)
- Helsinn Healthcare SA · 4 drugs in this class
- LG Life Sciences · 3 drugs in this class
- University of Malaya · 2 drugs in this class
- GlaxoSmithKline · 1 drug in this class
- Hamad Medical Corporation · 1 drug in this class
- Eye & ENT Hospital of Fudan University · 1 drug in this class
- Instituto Mexicano del Seguro Social · 1 drug in this class
- Chongqing University Cancer Hospital · 1 drug in this class
- Merck Sharp & Dohme LLC · 1 drug in this class
- MonoSol Rx · 1 drug in this class
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Cite this brief
Drug Landscape (2026). cardiac output changes with "ondansetron" — Competitive Intelligence Brief. https://druglandscape.com/ci/cardiac-output-changes-with-ondansetron. Accessed 2026-05-16.
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