Who are Buspirone HCl's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trintellix, Aripiprazole; Quetiapine, Aripiprazole tablet, Latuda©, Abilify (aripiprazole), Lithium or Valproate with Aripiprazole.

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Last reviewed 2026-06-10 · How we verify

Buspirone HCl — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Buspirone HCl (Buspirone HCl) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT1A receptor agonist. Area: Psychiatry/Neurology.

marketed 5-HT1A receptor agonist 5-HT1A receptor Psychiatry/Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Buspirone HCl (Buspirone HCl) — Par Pharmaceutical, Inc.. Buspirone acts as a serotonin 5-HT1A receptor agonist to reduce anxiety without the sedation or dependence associated with benzodiazepines.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Buspirone HCl TARGET	Buspirone HCl	Par Pharmaceutical, Inc.	marketed	5-HT1A receptor agonist	5-HT1A receptor
Trintellix	vortioxetine	Takeda	marketed	Serotonin modulator and stimulator (SMS); SSRI-like agent	Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor	2013-01-01
Aripiprazole; Quetiapine	Aripiprazole; Quetiapine	Taichung Veterans General Hospital	marketed	Atypical antipsychotic combination	Dopamine D2 receptor; Serotonin 5-HT2A receptor; Serotonin 5-HT1A receptor
Aripiprazole tablet	Aripiprazole tablet	All India Institute of Medical Sciences, Bhubaneswar	marketed	Atypical antipsychotic	Dopamine D2 receptor (partial agonist); Serotonin 5-HT1A receptor (partial agonist); Serotonin 5-HT2A receptor (antagonist)
Latuda©	Latuda©	University of North Carolina, Chapel Hill	marketed	Atypical antipsychotic	Dopamine D2 receptor, serotonin 5-HT7 receptor, serotonin 5-HT1A receptor
Abilify (aripiprazole)	Abilify (aripiprazole)	Genovate Biotechnology Co., Ltd.,	marketed	Atypical antipsychotic	Dopamine D2 receptor (partial agonist), Serotonin 5-HT1A receptor (partial agonist)
Lithium or Valproate with Aripiprazole	Lithium or Valproate with Aripiprazole	Otsuka Pharmaceutical Development & Commercialization, Inc.	marketed	Atypical antipsychotic combined with mood stabilizers	Dopamine D2/D3 receptors, serotonin 5-HT1A receptor (aripiprazole); inositol monophosphatase, GSK-3 (lithium); histone deacetylase (valproate)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT1A receptor agonist class)

Par Pharmaceutical, Inc. · 1 drug in this class
Sumitomo Pharma (Suzhou) Co., Ltd. · 1 drug in this class
Supernus Pharmaceuticals, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Buspirone HCl — Competitive Intelligence Brief. https://druglandscape.com/ci/buspirone-hcl. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing