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Brivanib 400 mg, BID — Competitive Intelligence Brief

Brivanib 400 mg, BID (Brivanib 400 mg, BID) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Dual FGFR/VEGFR inhibitor. Area: Oncology.

phase 2 Dual FGFR/VEGFR inhibitor FGFR, VEGFR Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Brivanib 400 mg, BID (Brivanib 400 mg, BID) — Zai Lab (Shanghai) Co., Ltd.. Brivanib is a dual inhibitor of fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) that blocks angiogenesis and tumor cell proliferation.

Comparator set (6 drugs)

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DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Brivanib 400 mg, BID TARGET Brivanib 400 mg, BID Zai Lab (Shanghai) Co., Ltd. phase 2 Dual FGFR/VEGFR inhibitor FGFR, VEGFR
pirfenidone or nintedanib pirfenidone or nintedanib Hospices Civils de Lyon marketed Antifibrotic agent Pirfenidone: TGF-β pathway; Nintedanib: FGFR, VEGFR, PDGFR tyrosine kinases
Lenvatinib + losartan Lenvatinib + losartan Second Affiliated Hospital of Xi'an Jiaotong University marketed Multi-targeted tyrosine kinase inhibitor + angiotensin II receptor antagonist FGFR, VEGFR, RET (lenvatinib); AT1 receptor (losartan)
Placebo matching lenvatinib Placebo matching lenvatinib Merck Sharp & Dohme LLC phase 3 Multi-targeted tyrosine kinase inhibitor FGFR, VEGFR, RET, KIT
AL3818 Capsule AL3818 Capsule Advenchen Laboratories Nanjing Ltd. phase 3 Multi-targeted tyrosine kinase inhibitor FGFR, VEGFR, and other receptor tyrosine kinases
Len-TACE Len-TACE Second Affiliated Hospital of Guangzhou Medical University phase 3 Multi-kinase inhibitor (combined with transarterial chemoembolization) FGFR, VEGFR, RET, KIT
Lenvatinib, tislelizumab, gemcitabine and cisplatin Lenvatinib, tislelizumab, gemcitabine and cisplatin Second Affiliated Hospital, School of Medicine, Zhejiang University phase 3 Multi-targeted tyrosine kinase inhibitor + PD-1 inhibitor + chemotherapy combination FGFR, VEGFR, RET (lenvatinib); PD-1 (tislelizumab); DNA (gemcitabine, cisplatin)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Dual FGFR/VEGFR inhibitor class)

  1. Zai Lab (Shanghai) Co., Ltd. · 2 drugs in this class

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Cite this brief

Drug Landscape (2026). Brivanib 400 mg, BID — Competitive Intelligence Brief. https://druglandscape.com/ci/brivanib-400-mg-bid. Accessed 2026-05-16.

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