Last reviewed · How we verify
Brivanib 400 mg, BID — Competitive Intelligence Brief
phase 2
Dual FGFR/VEGFR inhibitor
FGFR, VEGFR
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Brivanib 400 mg, BID (Brivanib 400 mg, BID) — Zai Lab (Shanghai) Co., Ltd.. Brivanib is a dual inhibitor of fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) that blocks angiogenesis and tumor cell proliferation.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Brivanib 400 mg, BID TARGET | Brivanib 400 mg, BID | Zai Lab (Shanghai) Co., Ltd. | phase 2 | Dual FGFR/VEGFR inhibitor | FGFR, VEGFR | |
| pirfenidone or nintedanib | pirfenidone or nintedanib | Hospices Civils de Lyon | marketed | Antifibrotic agent | Pirfenidone: TGF-β pathway; Nintedanib: FGFR, VEGFR, PDGFR tyrosine kinases | |
| Lenvatinib + losartan | Lenvatinib + losartan | Second Affiliated Hospital of Xi'an Jiaotong University | marketed | Multi-targeted tyrosine kinase inhibitor + angiotensin II receptor antagonist | FGFR, VEGFR, RET (lenvatinib); AT1 receptor (losartan) | |
| Placebo matching lenvatinib | Placebo matching lenvatinib | Merck Sharp & Dohme LLC | phase 3 | Multi-targeted tyrosine kinase inhibitor | FGFR, VEGFR, RET, KIT | |
| AL3818 Capsule | AL3818 Capsule | Advenchen Laboratories Nanjing Ltd. | phase 3 | Multi-targeted tyrosine kinase inhibitor | FGFR, VEGFR, and other receptor tyrosine kinases | |
| Len-TACE | Len-TACE | Second Affiliated Hospital of Guangzhou Medical University | phase 3 | Multi-kinase inhibitor (combined with transarterial chemoembolization) | FGFR, VEGFR, RET, KIT | |
| Lenvatinib, tislelizumab, gemcitabine and cisplatin | Lenvatinib, tislelizumab, gemcitabine and cisplatin | Second Affiliated Hospital, School of Medicine, Zhejiang University | phase 3 | Multi-targeted tyrosine kinase inhibitor + PD-1 inhibitor + chemotherapy combination | FGFR, VEGFR, RET (lenvatinib); PD-1 (tislelizumab); DNA (gemcitabine, cisplatin) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Dual FGFR/VEGFR inhibitor class)
- Zai Lab (Shanghai) Co., Ltd. · 2 drugs in this class
Subscribe to ongoing alerts
Push every new event for this competitive set into your RSS reader, IFTTT/Zapier workflow, or email digest:
- Brivanib 400 mg, BID CI watch — RSS
- Brivanib 400 mg, BID CI watch — Atom
- Brivanib 400 mg, BID CI watch — JSON
- Brivanib 400 mg, BID alone — RSS
- Whole Dual FGFR/VEGFR inhibitor class — RSS
Cite this brief
Drug Landscape (2026). Brivanib 400 mg, BID — Competitive Intelligence Brief. https://druglandscape.com/ci/brivanib-400-mg-bid. Accessed 2026-05-16.
Build your own brief
Pick any drug + add comparators:
https://druglandscape.com/ci/{slug}— auto-detected competitorshttps://druglandscape.com/ci/{slug}?vs=drug1,drug2,drug3— explicit comparators- Brand names auto-resolve:
/ci/keytruda→ 301 →/ci/pembrolizumab