Who are Brexanolone Injection [Zulresso]'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Zulresso, Onfi, Lusedra, Campral, Sonata, Suprane.

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Last reviewed 2026-05-16 · How we verify

Brexanolone Injection [Zulresso] — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brexanolone Injection [Zulresso] (Brexanolone Injection [Zulresso]) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Neuroactive steroid; GABA-A receptor positive allosteric modulator. Area: Psychiatry / Neurology.

marketed Neuroactive steroid; GABA-A receptor positive allosteric modulator GABA-A receptor Psychiatry / Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Brexanolone Injection [Zulresso] (Brexanolone Injection [Zulresso]) — Donald Jeffrey Newport. Brexanolone is a synthetic neuroactive steroid that acts as a positive allosteric modulator of GABA-A receptors to enhance inhibitory neurotransmission in the brain.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Brexanolone Injection [Zulresso] TARGET	Brexanolone Injection [Zulresso]	Donald Jeffrey Newport	marketed	Neuroactive steroid; GABA-A receptor positive allosteric modulator	GABA-A receptor
Zulresso	BREXANOLONE	Sage Therap	marketed	Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator	GABA-A receptor alpha-1/beta-2/gamma-2	2019-01-01
Onfi	CLOBAZAM	Lundbeck Pharms Llc	marketed	Benzodiazepine [EPC]	GABA-A receptor alpha-1/beta-2/gamma-2	2011-01-01
Lusedra	FOSPROPOFOL		marketed	fospropofol	GABA-A receptor	2008-01-01
Campral	ACAMPROSATE	Allergan/AbbVie	marketed	acamprosate	GABA-A receptor alpha-1/beta-3/gamma-2	2004-01-01
Sonata	ZALEPLON	Pfizer	marketed	gamma-Aminobutyric Acid A Receptor Agonist [EPC]	GABA-A receptor alpha-1/beta-2/gamma-2	1999-01-01
Suprane	DESFLURANE	Baxter	marketed	General Anesthetic [EPC]	GABA-A receptor; anion channel	1992-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2039-09-05 — Onfi · 12403090 · Formulation · US
2039-09-05 — Onfi · 12290597 · Formulation · US
2040-01-31 — Onfi · 11541002 · Formulation · US

Sponsor landscape (Neuroactive steroid; GABA-A receptor positive allosteric modulator class)

Donald Jeffrey Newport · 1 drug in this class
Neurelis, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Brexanolone Injection [Zulresso] — Competitive Intelligence Brief. https://druglandscape.com/ci/brexanolone-injection-zulresso. Accessed 2026-05-16.

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