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BERLIM 25/10 association — Competitive Intelligence Brief
phase 3
Angiotensin II receptor antagonist + thiazide diuretic combination
AT1 receptor (angiotensin II type 1 receptor); thiazide-sensitive sodium-chloride cotransporter
Cardiovascular
Small molecule
Live · refreshed every 30 min
Target snapshot
BERLIM 25/10 association (BERLIM 25/10 association) — EMS. BERLIM 25/10 is a fixed-dose combination of losartan (angiotensin II receptor antagonist) and hydrochlorothiazide (thiazide diuretic) that reduces blood pressure through dual antihypertensive pathways.
Comparator set (3 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| BERLIM 25/10 association TARGET | BERLIM 25/10 association | EMS | phase 3 | Angiotensin II receptor antagonist + thiazide diuretic combination | AT1 receptor (angiotensin II type 1 receptor); thiazide-sensitive sodium-chloride cotransporter | |
| hydrochlorothiazide, losartan | hydrochlorothiazide, losartan | University Hospital, Strasbourg, France | marketed | Angiotensin II receptor antagonist + thiazide diuretic combination | AT1 receptor (losartan); sodium-chloride cotransporter (hydrochlorothiazide) | |
| BERLIM 25/20 ASSOCIATION | BERLIM 25/20 ASSOCIATION | EMS | phase 3 | Angiotensin II receptor antagonist + thiazide diuretic combination | AT1 receptor (angiotensin II type 1 receptor); thiazide-sensitive sodium-chloride cotransporter | |
| Losartan + hydrochlorothiazide in fixed dose | Losartan + hydrochlorothiazide in fixed dose | Laboratorios Silanes S.A. de C.V. | phase 3 | Angiotensin II receptor antagonist + thiazide diuretic combination | AT1 receptor (angiotensin II type 1 receptor); sodium-chloride cotransporter |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Angiotensin II receptor antagonist + thiazide diuretic combination class)
- EMS · 2 drugs in this class
- Laboratorios Silanes S.A. de C.V. · 1 drug in this class
- University Hospital, Strasbourg, France · 1 drug in this class
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- BERLIM 25/10 association alone — RSS
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Cite this brief
Drug Landscape (2026). BERLIM 25/10 association — Competitive Intelligence Brief. https://druglandscape.com/ci/berlim-25-10-association. Accessed 2026-05-16.
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