Who are Baclofen ER's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lioresal, Low Sodium Oxybate, placebo + oral baclofen, Sodium Oxybate (SMO), Xyrem, FT218.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

Baclofen ER — Competitive Intelligence Brief

Baclofen ER (Baclofen ER) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: GABA-B receptor agonist. Area: Neurology.

marketed GABA-B receptor agonist GABA-B receptor Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Baclofen ER (Baclofen ER) — Alkermes, Inc.. Baclofen ER is a GABA-B receptor agonist that reduces neuronal excitability and muscle tone by enhancing inhibitory neurotransmission in the central nervous system.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Baclofen ER TARGET	Baclofen ER	Alkermes, Inc.	marketed	GABA-B receptor agonist	GABA-B receptor
Lioresal	BACLOFEN		marketed	gamma-Aminobutyric Acid-ergic Agonist [EPC]	GABA-B receptor	1977-01-01
Low Sodium Oxybate	Low Sodium Oxybate	Leiden University Medical Center	marketed	GHB receptor agonist / GABA-B receptor agonist	GHB receptor, GABA-B receptor
placebo + oral baclofen	placebo + oral baclofen	Shaare Zedek Medical Center	marketed	GABA-B receptor agonist	GABA-B receptor
Sodium Oxybate (SMO)	Sodium Oxybate (SMO)	Catholic University of the Sacred Heart	marketed	GABA-B receptor agonist; CNS depressant	GABA-B receptor
Xyrem	Xyrem	Jazz Pharmaceuticals	marketed		Calcium/calmodulin-dependent protein kinase type II subunit alpha, GABA-B receptor, Gamma-hydroxybutyrate receptor
FT218	FT218	Avadel	phase 3	Sodium oxybate (extended-release formulation)	GABA-B receptor (indirect mechanism via sodium oxybate metabolite)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2037-09-08 — Lioresal · 11446246 · Method of Use · US
2037-09-29 — Lioresal · 11324696 · Formulation · US
2039-07-29 — Lioresal · 11654124 · Formulation · US
2039-07-29 — Lioresal · 10792262 · Formulation · US
2039-07-29 — Lioresal · 11931328 · Formulation · US
2039-08-30 — Lioresal · 10610502 · Method of Use · US
2041-09-29 — Lioresal · 11850225 · Formulation · US
2041-09-29 — Lioresal · 11491125 · Formulation · US

Sponsor landscape (GABA-B receptor agonist class)

Alkermes, Inc. · 1 drug in this class
Shaare Zedek Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Baclofen ER — Competitive Intelligence Brief. https://druglandscape.com/ci/baclofen-er. Accessed 2026-05-13.

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