Who are AXS-12 (Reboxetine)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Strattera (atomoxetine), atomoxetine (or placebo), Atomoxetine (Strattera), Atomoxetine (ATO), SPN-812 (600mg, QD), Reboxetine Pill.

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Last reviewed 2026-05-16 · How we verify

AXS-12 (Reboxetine) — Competitive Intelligence Brief

AXS-12 (Reboxetine) (AXS-12 (Reboxetine)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Norepinephrine reuptake inhibitor (NRI). Area: Psychiatry / Neurology.

phase 3 Norepinephrine reuptake inhibitor (NRI) Norepinephrine transporter (NET) Psychiatry / Neurology Small molecule Live · refreshed every 30 min

Target snapshot

AXS-12 (Reboxetine) (AXS-12 (Reboxetine)) — Axsome Therapeutics, Inc.. Reboxetine is a selective norepinephrine reuptake inhibitor (NRI) that increases norepinephrine levels in the brain by blocking its reuptake at the presynaptic neuron.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
AXS-12 (Reboxetine) TARGET	AXS-12 (Reboxetine)	Axsome Therapeutics, Inc.	phase 3	Norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)
Strattera (atomoxetine)	Strattera (atomoxetine)	Massachusetts General Hospital	marketed	Selective norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)
atomoxetine (or placebo)	atomoxetine (or placebo)	University of Arizona	marketed	Norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)
Atomoxetine (Strattera)	Atomoxetine (Strattera)	University of Pittsburgh	marketed	Norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)
Atomoxetine (ATO)	Atomoxetine (ATO)	Janssen Research & Development, LLC	marketed	Norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)
SPN-812 (600mg, QD)	SPN-812 (600mg, QD)	Supernus Pharmaceuticals, Inc.	marketed	Selective norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)
Reboxetine Pill	Reboxetine Pill	Vrije Universiteit Brussel	phase 3	Norepinephrine reuptake inhibitor (NRI)	Norepinephrine transporter (NET)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Norepinephrine reuptake inhibitor (NRI) class)

Axsome Therapeutics, Inc. · 2 drugs in this class
Janssen Research & Development, LLC · 1 drug in this class
Mallinckrodt · 1 drug in this class
University of Arizona · 1 drug in this class
University of Pittsburgh · 1 drug in this class
Vrije Universiteit Brussel · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AXS-12 (Reboxetine) — Competitive Intelligence Brief. https://druglandscape.com/ci/axs-12-reboxetine. Accessed 2026-05-16.

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