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AT-527 single dose — Competitive Intelligence Brief
phase 1
nucleoside analog
viral RNA-dependent RNA polymerase
Infectious Disease
Small molecule
Live · refreshed every 30 min
Target snapshot
AT-527 single dose (AT-527 single dose) — Atea Pharmaceuticals, Inc.. AT-527 is a nucleoside analog that inhibits viral RNA-dependent RNA polymerase, thereby blocking viral replication.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| AT-527 single dose TARGET | AT-527 single dose | Atea Pharmaceuticals, Inc. | phase 1 | nucleoside analog | viral RNA-dependent RNA polymerase | |
| Ribavirin "loading" dose given | Ribavirin "loading" dose given | Göteborg University | marketed | Nucleoside analog antiviral | Viral RNA-dependent RNA polymerase; IMPDH (inosine monophosphate dehydrogenase) | |
| D: Peg-interferon alpha-2a & Ribavirin | D: Peg-interferon alpha-2a & Ribavirin | Kaohsiung Medical University Chung-Ho Memorial Hospital | marketed | Antiviral combination therapy | Interferon-alpha receptor (IFNAR); viral RNA-dependent RNA polymerase | |
| pegylated interferon alpha 2a, ribavirin | pegylated interferon alpha 2a, ribavirin | Kaohsiung Medical University Chung-Ho Memorial Hospital | marketed | Antiviral combination therapy | Interferon-alpha receptor (IFNAR); viral RNA-dependent RNA polymerase | |
| standard treatment COVID-19 + Triazavirin | standard treatment COVID-19 + Triazavirin | Ain Shams University | marketed | Nucleoside analog antiviral | Viral RNA-dependent RNA polymerase (RdRp) | |
| Infergen and ribavirin | Infergen and ribavirin | Kadmon Corporation, LLC | marketed | Interferon alpha and nucleoside analog combination | Interferon-alpha receptor (IFNAR); viral RNA-dependent RNA polymerase | |
| E: Peg-interferon alpha-2a & Ribavirin | E: Peg-interferon alpha-2a & Ribavirin | Kaohsiung Medical University Chung-Ho Memorial Hospital | marketed | Antiviral combination therapy | Interferon-alpha receptor; viral RNA-dependent RNA polymerase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (nucleoside analog class)
- Atea Pharmaceuticals, Inc. · 1 drug in this class
- Bausch & Lomb Incorporated · 1 drug in this class
- Medivir · 1 drug in this class
- Tarapeutics Science Inc. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). AT-527 single dose — Competitive Intelligence Brief. https://druglandscape.com/ci/at-527-single-dose. Accessed 2026-05-14.
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