Who are ARQ-151 cream 0.3%'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Otezla, Crisaborole ointment, 2%, Apremilast (CC-10004), Crisaborole Vehicle, GSK 1437173A, ARQ-151 vehicle cream.

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Last reviewed 2026-05-16 · How we verify

ARQ-151 cream 0.3% — Competitive Intelligence Brief

ARQ-151 cream 0.3% (ARQ-151 cream 0.3%) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Phosphodiesterase 4 (PDE4) inhibitor. Area: Dermatology.

phase 3 Phosphodiesterase 4 (PDE4) inhibitor PDE4 Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

ARQ-151 cream 0.3% (ARQ-151 cream 0.3%) — Arcutis Biotherapeutics, Inc.. ARQ-151 is a topical phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
ARQ-151 cream 0.3% TARGET	ARQ-151 cream 0.3%	Arcutis Biotherapeutics, Inc.	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Otezla	APREMILAST	Amgen	marketed	Phosphodiesterase 4 Inhibitor [EPC]	PDE4	2014-01-01
Crisaborole ointment, 2%	Crisaborole ointment, 2%	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Apremilast (CC-10004)	Apremilast (CC-10004)	Virginia Clinical Research, Inc.	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Crisaborole Vehicle	Crisaborole Vehicle	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
GSK 1437173A	GSK 1437173A	GlaxoSmithKline	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
ARQ-151 vehicle cream	ARQ-151 vehicle cream	Arcutis Biotherapeutics, Inc.	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Phosphodiesterase 4 (PDE4) inhibitor class)

Pfizer · 6 drugs in this class
Shire · 3 drugs in this class
Almirall, S.A. · 3 drugs in this class
Arcutis Biotherapeutics, Inc. · 2 drugs in this class
LEO Pharma · 2 drugs in this class
ORA, Inc. · 1 drug in this class
Tillotts Pharma AG · 1 drug in this class
AbbVie (prior sponsor, Abbott) · 1 drug in this class
Virginia Clinical Research, Inc. · 1 drug in this class
Alfasigma S.p.A. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). ARQ-151 cream 0.3% — Competitive Intelligence Brief. https://druglandscape.com/ci/arq-151-cream-0-3. Accessed 2026-05-16.

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