Last reviewed · How we verify
Aprepitant plus Olanzapine — Competitive Intelligence Brief
phase 3
NK1 receptor antagonist + atypical antipsychotic combination
Neurokinin-1 (NK1) receptor; dopamine D2 receptor; serotonin 5-HT2A receptor
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Aprepitant plus Olanzapine (Aprepitant plus Olanzapine) — Rush University Medical Center. Aprepitant blocks substance P neurokinin-1 receptors while olanzapine antagonizes dopamine and serotonin receptors, together providing enhanced antiemetic and anti-nausea effects.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Aprepitant plus Olanzapine TARGET | Aprepitant plus Olanzapine | Rush University Medical Center | phase 3 | NK1 receptor antagonist + atypical antipsychotic combination | Neurokinin-1 (NK1) receptor; dopamine D2 receptor; serotonin 5-HT2A receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (NK1 receptor antagonist + atypical antipsychotic combination class)
- Rush University Medical Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Aprepitant plus Olanzapine — Competitive Intelligence Brief. https://druglandscape.com/ci/aprepitant-plus-olanzapine. Accessed 2026-06-10.
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