Who are Apremilast (CC-10004)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Otezla, Crisaborole Vehicle, Crisaborole ointment, 2%, SPD503 (4 mg), PF-06410293, LAS41008.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Apremilast (CC-10004) — Competitive Intelligence Brief

Apremilast (CC-10004) (Apremilast (CC-10004)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Phosphodiesterase 4 (PDE4) inhibitor. Area: Immunology.

marketed Phosphodiesterase 4 (PDE4) inhibitor PDE4 Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Apremilast (CC-10004) (Apremilast (CC-10004)) — Virginia Clinical Research, Inc.. Apremilast inhibits phosphodiesterase 4 (PDE4) to reduce inflammatory cytokine production and modulate immune cell function.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Apremilast (CC-10004) TARGET	Apremilast (CC-10004)	Virginia Clinical Research, Inc.	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Otezla	APREMILAST	Amgen	marketed	Phosphodiesterase 4 Inhibitor [EPC]	PDE4	2014-01-01
Crisaborole Vehicle	Crisaborole Vehicle	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Crisaborole ointment, 2%	Crisaborole ointment, 2%	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
SPD503 (4 mg)	SPD503 (4 mg)	Shire	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
PF-06410293	PF-06410293	Pfizer	phase 3	PDE4 inhibitor	PDE4
LAS41008	LAS41008	Almirall, S.A.	phase 3	PDE4 inhibitor	PDE4

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Phosphodiesterase 4 (PDE4) inhibitor class)

Pfizer · 6 drugs in this class
Shire · 3 drugs in this class
Almirall, S.A. · 3 drugs in this class
Arcutis Biotherapeutics, Inc. · 2 drugs in this class
LEO Pharma · 2 drugs in this class
ORA, Inc. · 1 drug in this class
Tillotts Pharma AG · 1 drug in this class
AbbVie (prior sponsor, Abbott) · 1 drug in this class
Virginia Clinical Research, Inc. · 1 drug in this class
Alfasigma S.p.A. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Apremilast (CC-10004) — Competitive Intelligence Brief. https://druglandscape.com/ci/apremilast-cc-10004. Accessed 2026-05-16.

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