Who are AON-D21's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Itovebi, Piqray, Placebo followed by Fisetin, SBR759A, AG20011, GDC-229.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

How do I get this as a recurring report?

Subscribe to /feed/ci/aon-d21.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

AON-D21 — Competitive Intelligence Brief

AON-D21 (AON-D21) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: PI3K inhibitor. Area: Oncology.

phase 2 PI3K inhibitor PI3K Oncology Small molecule Live · refreshed every 30 min

Target snapshot

AON-D21 (AON-D21) — Aptarion Biotech AG. AON-D21 is a small molecule that targets the PI3K/AKT/mTOR pathway.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
AON-D21 TARGET	AON-D21	Aptarion Biotech AG	phase 2	PI3K inhibitor	PI3K
Itovebi	inavolisib	Pfizer	marketed	Kinase Inhibitor [EPC]	phosphatidylinositol 3-kinase (PI3K) alpha (PIK3CA)	2024-01-01
Piqray	alpelisib	Novartis	marketed		PI3Kα	2019-01-01
Placebo followed by Fisetin	Placebo followed by Fisetin	Wake Forest University Health Sciences	marketed	Senolytic agent	Multiple targets including PI3K/Akt and p38 MAPK pathways in senescent cells
SBR759A	SBR759A	Novartis	phase 3	PI3K inhibitor	PI3K
AG20011	AG20011	Ahn-Gook Pharmaceuticals Co.,Ltd	phase 3	PI3K inhibitor	PI3K
GDC-229	GDC-229	Balmoral Medical company	phase 3	PI3K inhibitor	PI3K

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (PI3K inhibitor class)

Addpharma Inc. · 4 drugs in this class
AstraZeneca · 3 drugs in this class
Bayer · 3 drugs in this class
Ahn-Gook Pharmaceuticals Co.,Ltd · 2 drugs in this class
InventisBio Co., Ltd · 2 drugs in this class
Orient Pharma Co., Ltd. · 2 drugs in this class
Applied Biology, Inc. · 1 drug in this class
Angitia Incorporated Limited · 1 drug in this class
Aevi Genomic Medicine, LLC, a Cerecor company · 1 drug in this class
BPGbio · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AON-D21 — Competitive Intelligence Brief. https://druglandscape.com/ci/aon-d21. Accessed 2026-05-13.

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