Who are Angiomax (bivalirudin)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Pradaxa, Pradaxa, Dabigatran etexilate (Pradaxa), Bivalirudin with and without eptifibatide, prasugrel/bivalirudin, Pradaxa (Dabigatran etexilate).

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Last reviewed 2026-05-16 · How we verify

Angiomax (bivalirudin) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Angiomax (bivalirudin) (Angiomax (bivalirudin)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Direct thrombin inhibitor. Area: Cardiovascular.

phase 3 Direct thrombin inhibitor Thrombin (Factor IIa) Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Angiomax (bivalirudin) (Angiomax (bivalirudin)) — The Medicines Company. Bivalirudin is a direct thrombin inhibitor that binds to and blocks thrombin, preventing blood clot formation.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Angiomax (bivalirudin) TARGET	Angiomax (bivalirudin)	The Medicines Company	phase 3	Direct thrombin inhibitor	Thrombin (Factor IIa)
Pradaxa	dabigatran etexilate	Generic (originally Boehringer Ingelheim)	marketed	Direct oral anticoagulant (DOAC) — direct thrombin inhibitor	Multidrug and toxin extrusion protein 1, Multidrug and toxin extrusion protein 2, Ribosyldihydronicotinamide dehydrogenase [quinone]	2010-10-19
Pradaxa	dabigatran-etexilate	Boehringer Ingelheim	marketed	Direct thrombin inhibitor	Thrombin (serine protease)	2010-01-01
Dabigatran etexilate (Pradaxa)	Dabigatran etexilate (Pradaxa)	Bayer	marketed	Direct thrombin inhibitor (DTI)	Thrombin (Factor IIa)
Bivalirudin with and without eptifibatide	Bivalirudin with and without eptifibatide	LifeBridge Health	marketed	Direct thrombin inhibitor (bivalirudin) + Glycoprotein IIb/IIIa inhibitor (eptifibatide)	Thrombin (Factor IIa) and Glycoprotein IIb/IIIa receptor
prasugrel/bivalirudin	prasugrel/bivalirudin	I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio	marketed	Antiplatelet agent + Direct thrombin inhibitor combination	P2Y12 receptor (prasugrel); Thrombin (bivalirudin)
Pradaxa (Dabigatran etexilate)	Pradaxa (Dabigatran etexilate)	Bayer	marketed	Direct thrombin inhibitor (anticoagulant)	Thrombin (Factor IIa)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-08-31 — Pradaxa · 7866474 · US
2028-03-02 — Pradaxa · 7866474*PED · US
2031-01-20 — Pradaxa · 9034822 · US
2031-07-20 — Pradaxa · 9034822*PED · US

Sponsor landscape (Direct thrombin inhibitor class)

Bayer · 2 drugs in this class
Boehringer Ingelheim · 1 drug in this class
MinaPharm Pharmaceuticals · 1 drug in this class
Ono Pharmaceutical Co. Ltd · 1 drug in this class
The Medicines Company · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Angiomax (bivalirudin) — Competitive Intelligence Brief. https://druglandscape.com/ci/angiomax-bivalirudin. Accessed 2026-05-16.

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