Who are AN2728 Topical Ointment, 0.5% QD's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Otezla, Crisaborole Vehicle, Apremilast (CC-10004), Crisaborole ointment, 2%, (PN-152,243)/ PN-196,444, GW685698X.

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Last reviewed 2026-05-16 · How we verify

AN2728 Topical Ointment, 0.5% QD — Competitive Intelligence Brief

AN2728 Topical Ointment, 0.5% QD (AN2728 Topical Ointment, 0.5% QD) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Phosphodiesterase 4 (PDE4) inhibitor. Area: Dermatology.

phase 2 Phosphodiesterase 4 (PDE4) inhibitor PDE4 Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

AN2728 Topical Ointment, 0.5% QD (AN2728 Topical Ointment, 0.5% QD) — Pfizer. AN2728 is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin cells when applied topically.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
AN2728 Topical Ointment, 0.5% QD TARGET	AN2728 Topical Ointment, 0.5% QD	Pfizer	phase 2	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Otezla	APREMILAST	Amgen	marketed	Phosphodiesterase 4 Inhibitor [EPC]	PDE4	2014-01-01
Crisaborole Vehicle	Crisaborole Vehicle	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Apremilast (CC-10004)	Apremilast (CC-10004)	Virginia Clinical Research, Inc.	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Crisaborole ointment, 2%	Crisaborole ointment, 2%	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
(PN-152,243)/ PN-196,444	(PN-152,243)/ PN-196,444	Pfizer	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
GW685698X	GW685698X	GlaxoSmithKline	phase 3	PDE4 inhibitor	PDE4

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Phosphodiesterase 4 (PDE4) inhibitor class)

Pfizer · 6 drugs in this class
Shire · 3 drugs in this class
Almirall, S.A. · 3 drugs in this class
Arcutis Biotherapeutics, Inc. · 2 drugs in this class
LEO Pharma · 2 drugs in this class
ORA, Inc. · 1 drug in this class
Tillotts Pharma AG · 1 drug in this class
AbbVie (prior sponsor, Abbott) · 1 drug in this class
Virginia Clinical Research, Inc. · 1 drug in this class
Alfasigma S.p.A. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AN2728 Topical Ointment, 0.5% QD — Competitive Intelligence Brief. https://druglandscape.com/ci/an2728-topical-ointment-0-5-qd. Accessed 2026-05-16.

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