Who are Amitiza (Lubiprostone)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): lubiprostone (Amitiza), Lubiprostone 24, Cohort 1: Lubiprostone Capsule, Fasted, Amitiza.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Amitiza (Lubiprostone) — Competitive Intelligence Brief

Amitiza (Lubiprostone) (Amitiza (Lubiprostone)) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Chloride channel activator. Area: Gastroenterology.

marketed Chloride channel activator ClC-2 chloride channel Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

Amitiza (Lubiprostone) (Amitiza (Lubiprostone)) — Brooke Army Medical Center. Lubiprostone activates ClC-2 chloride channels in the intestinal epithelium to increase fluid secretion into the bowel lumen, promoting stool passage.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Amitiza (Lubiprostone) TARGET	Amitiza (Lubiprostone)	Brooke Army Medical Center	marketed	Chloride channel activator	ClC-2 chloride channel
lubiprostone (Amitiza)	lubiprostone (Amitiza)	Henry Ford Health System	marketed	ClC-2 chloride channel activator	ClC-2 chloride channel
Lubiprostone 24	Lubiprostone 24	Sucampo Pharma Americas, LLC	phase 3	ClC-2 chloride channel activator	ClC-2 chloride channel
Cohort 1: Lubiprostone Capsule, Fasted	Cohort 1: Lubiprostone Capsule, Fasted	Sucampo Pharma Americas, LLC	phase 3	Chloride channel activator	ClC-2 chloride channel
Amitiza	LUBIPROSTONE	Sucampo Pharma Llc	marketed	Chloride Channel Activator [EPC]	Chloride channel protein 2	2006-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Chloride channel activator class)

Brooke Army Medical Center · 1 drug in this class
Sucampo Pharma Americas, LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Amitiza (Lubiprostone) — Competitive Intelligence Brief. https://druglandscape.com/ci/amitiza-lubiprostone. Accessed 2026-05-14.

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