Who are AMG 714's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Tocilizumab plus methotrexate, Placebo to tocilizumab, Ro-Actemra, tocilizumab [RoActemra/Actemra], Tocilizumab(400mg), Actemra +MTX.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

AMG 714 — Competitive Intelligence Brief

AMG 714 (AMG 714) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: IL-6 receptor antagonist. Area: Immunology.

phase 2 IL-6 receptor antagonist IL-6R (Interleukin-6 receptor) Immunology Biologic Live · refreshed every 30 min

Target snapshot

AMG 714 (AMG 714) — Amgen. AMG 714 is an interleukin-6 (IL-6) receptor antagonist that blocks IL-6 signaling to reduce inflammation.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
AMG 714 TARGET	AMG 714	Amgen	phase 2	IL-6 receptor antagonist	IL-6R (Interleukin-6 receptor)
Tocilizumab plus methotrexate	Tocilizumab plus methotrexate	SURPRISE Study Group	marketed	IL-6 receptor antagonist + DMARD combination	IL-6 receptor (tocilizumab); dihydrofolate reductase (methotrexate)
Placebo to tocilizumab	Placebo to tocilizumab	Hoffmann-La Roche	marketed	IL-6 receptor antagonist	IL-6 receptor (IL-6R)
Ro-Actemra	Ro-Actemra	Medical University of Vienna	marketed	IL-6 receptor antagonist	IL-6R (Interleukin-6 receptor)
tocilizumab [RoActemra/Actemra]	tocilizumab [RoActemra/Actemra]	Hoffmann-La Roche	marketed	IL-6 receptor antagonist (monoclonal antibody)	IL-6 receptor (IL-6R)
Tocilizumab(400mg)	Tocilizumab(400mg)	Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University	marketed	IL-6 receptor antagonist (monoclonal antibody)	IL-6 receptor (IL-6R)
Actemra +MTX	Actemra +MTX	Zhejiang Hisun Pharmaceutical Co. Ltd.	phase 3	IL-6 receptor antagonist (monoclonal antibody)	IL-6 receptor (IL-6R)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (IL-6 receptor antagonist class)

Hoffmann-La Roche · 4 drugs in this class
Medical University of Vienna · 2 drugs in this class
Bio-Thera Solutions · 1 drug in this class
Biogipuzkoa Health Research Institute · 1 drug in this class
Abderrahmane Mami Hospital · 1 drug in this class
GlaxoSmithKline · 1 drug in this class
Centre Hospitalier Universitaire Dijon · 1 drug in this class
Amgen · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AMG 714 — Competitive Intelligence Brief. https://druglandscape.com/ci/amg-714. Accessed 2026-05-13.

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