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AK112, Gemcitabine, Cisplatin — Competitive Intelligence Brief
phase 3
Bispecific antibody (PD-1/LAG-3 inhibitor) combined with chemotherapy
PD-1 and LAG-3
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
AK112, Gemcitabine, Cisplatin (AK112, Gemcitabine, Cisplatin) — Akeso. AK112 is a bispecific antibody that simultaneously engages PD-1 and LAG-3 to enhance anti-tumor immune responses, while gemcitabine and cisplatin are chemotherapy agents that damage tumor DNA.
Comparator set (5 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| AK112, Gemcitabine, Cisplatin TARGET | AK112, Gemcitabine, Cisplatin | Akeso | phase 3 | Bispecific antibody (PD-1/LAG-3 inhibitor) combined with chemotherapy | PD-1 and LAG-3 | |
| Nivolumab + Relatlimab | Nivolumab + Relatlimab | H. Lee Moffitt Cancer Center and Research Institute | marketed | Dual checkpoint inhibitor (PD-1 and LAG-3 inhibitor combination) | PD-1 and LAG-3 | |
| AK112, Carboplatin, Paxlitaxel | AK112, Carboplatin, Paxlitaxel | Akeso | phase 3 | Bispecific antibody (PD-1/LAG-3 inhibitor) + chemotherapy combination | PD-1 and LAG-3 | |
| BAT2206 | BAT2206 | Bio-Thera Solutions | phase 3 | Bispecific antibody; dual checkpoint inhibitor | Likely PD-1 and LAG-3 (or similar dual checkpoint targets) | |
| TAR-210 | TAR-210 | Janssen Research & Development, LLC | phase 3 | Bispecific antibody | PD-1 and LAG-3 | |
| Nivolumab-relatlimab FDC | Nivolumab-relatlimab FDC | Bristol-Myers Squibb | phase 3 | Dual checkpoint inhibitor (PD-1/LAG-3) | PD-1 and LAG-3 |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Bispecific antibody (PD-1/LAG-3 inhibitor) combined with chemotherapy class)
- Akeso · 1 drug in this class
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Cite this brief
Drug Landscape (2026). AK112, Gemcitabine, Cisplatin — Competitive Intelligence Brief. https://druglandscape.com/ci/ak112-gemcitabine-cisplatin. Accessed 2026-05-18.
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