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Adjunct brexpiprazole — Competitive Intelligence Brief
phase 3
Serotonin-dopamine activity modulator (SDAM)
Dopamine D2 receptor, Serotonin 5-HT1A receptor
Psychiatry
Small molecule
Live · refreshed every 30 min
Target snapshot
Adjunct brexpiprazole (Adjunct brexpiprazole) — H. Lundbeck A/S. Brexpiprazole is a serotonin-dopamine activity modulator (SDAM) that acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, used as an adjunctive treatment to enhance antidepressant efficacy.
Comparator set (5 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Adjunct brexpiprazole TARGET | Adjunct brexpiprazole | H. Lundbeck A/S | phase 3 | Serotonin-dopamine activity modulator (SDAM) | Dopamine D2 receptor, Serotonin 5-HT1A receptor | |
| Abilify MyCite® | Abilify MyCite® | Otsuka Pharmaceutical Development & Commercialization, Inc. | marketed | Atypical antipsychotic with digital adherence monitoring | Dopamine D2 receptor, serotonin 5-HT1A receptor | |
| Aripiprazole (Fixed dose) | Aripiprazole (Fixed dose) | Otsuka Pharmaceutical Co., Ltd. | phase 3 | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT1A receptor | |
| Brexpiprazole +ADT | Brexpiprazole +ADT | Otsuka Pharmaceutical Development & Commercialization, Inc. | phase 3 | Atypical antipsychotic (dopamine D2 partial agonist) | Dopamine D2 receptor, Serotonin 5-HT1A receptor | |
| Brexpiprazole (OPC-34712) | Brexpiprazole (OPC-34712) | Otsuka Pharmaceutical Development & Commercialization, Inc. | phase 3 | Atypical antipsychotic; serotonin-dopamine activity modulator (SDAM) | Dopamine D2 receptor (partial agonist); serotonin 5-HT1A receptor (partial agonist); serotonin 5-HT2A receptor (antagonist) | |
| OPC-34712FUM/ Brexpiprazole fumarate | OPC-34712FUM/ Brexpiprazole fumarate | Otsuka Pharmaceutical Co., Ltd. | phase 3 | Serotonin-dopamine activity modulator (SDAM); atypical antipsychotic | Dopamine D2 receptor (partial agonist), serotonin 5-HT1A receptor (partial agonist), serotonin 5-HT2A receptor (antagonist) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Serotonin-dopamine activity modulator (SDAM) class)
- H. Lundbeck A/S · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Adjunct brexpiprazole — Competitive Intelligence Brief. https://druglandscape.com/ci/adjunct-brexpiprazole. Accessed 2026-05-14.
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