Who are AD-227B's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Clozaril, Adjunctive asenapine, Aripiprazole; Quetiapine, placebo with Clozapine, Aripiprazole tablet, paliperidone clozapine.

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Last reviewed 2026-05-15 · How we verify

AD-227B — Competitive Intelligence Brief

AD-227B (AD-227B) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Serotonin receptor antagonist. Area: Psychiatry.

phase 3 Serotonin receptor antagonist 5-HT2A Psychiatry Small molecule Live · refreshed every 30 min

Target snapshot

AD-227B (AD-227B) — Addpharma Inc.. AD-227B is a small molecule that targets the serotonin receptor 5-HT2A.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
AD-227B TARGET	AD-227B	Addpharma Inc.	phase 3	Serotonin receptor antagonist	5-HT2A
Clozaril	CLOZAPINE	Jazz Pharmaceuticals	marketed	Atypical Antipsychotic [EPC]	D2, 5-HT2A	1989-01-01
Adjunctive asenapine	Adjunctive asenapine	Lori Davis, MD	marketed	Atypical antipsychotic	D2 dopamine receptor, 5-HT2A serotonin receptor
Aripiprazole; Quetiapine	Aripiprazole; Quetiapine	Taichung Veterans General Hospital	marketed	Atypical antipsychotic combination	Dopamine D2 receptor; Serotonin 5-HT2A receptor; Serotonin 5-HT1A receptor
placebo with Clozapine	placebo with Clozapine	Shanghai Mental Health Center	marketed	Atypical antipsychotic	Dopamine D2 receptor, Serotonin 5-HT2A receptor
Aripiprazole tablet	Aripiprazole tablet	All India Institute of Medical Sciences, Bhubaneswar	marketed	Atypical antipsychotic	Dopamine D2 receptor (partial agonist); Serotonin 5-HT1A receptor (partial agonist); Serotonin 5-HT2A receptor (antagonist)
paliperidone clozapine	paliperidone clozapine	Universidad Nacional de Rosario	marketed	Atypical antipsychotic	Dopamine D2 receptor, Serotonin 5-HT2A receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2028-05-01 — Clozaril · 8057811 · Formulation · US

Sponsor landscape (Serotonin receptor antagonist class)

Addpharma Inc. · 2 drugs in this class
Shire · 2 drugs in this class
Gedeon Richter Plc. · 1 drug in this class
Geropharm · 1 drug in this class
H. Lundbeck A/S · 1 drug in this class
Infan Industria Quimica Farmaceutica Nacional · 1 drug in this class
Phytopharm Consulting Brazil · 1 drug in this class
Taisho Pharmaceutical Co., Ltd. · 1 drug in this class
Aclaris Therapeutics, Inc. · 1 drug in this class
Visirna Therapeutics HK Limited · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AD-227B — Competitive Intelligence Brief. https://druglandscape.com/ci/ad-227b. Accessed 2026-05-15.

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