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ACT-539313 — Competitive Intelligence Brief
phase 2
Dopamine D2 receptor antagonist
D2 receptor
Psychiatry
Small molecule
Live · refreshed every 30 min
Target snapshot
ACT-539313 (ACT-539313) — Idorsia Pharmaceuticals Ltd.. ACT-539313 is a selective dopamine D2 receptor antagonist.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| ACT-539313 TARGET | ACT-539313 | Idorsia Pharmaceuticals Ltd. | phase 2 | Dopamine D2 receptor antagonist | D2 receptor | |
| Risperidone tablets | Risperidone tablets | Sumitomo Pharma (Suzhou) Co., Ltd. | marketed | Atypical antipsychotic | Dopamine D2 receptor; Serotonin 5-HT2A receptor | |
| Risperidone, Haloperidol | Risperidone, Haloperidol | Ludwig-Maximilians - University of Munich | marketed | Antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor | |
| Risperdal Consta | Risperdal Consta | Zogenix, Inc. | marketed | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor | |
| Risperidone, divalproex | Risperidone, divalproex | Nathan Kline Institute for Psychiatric Research | marketed | Atypical antipsychotic + anticonvulsant mood stabilizer combination | Dopamine D2 receptor (risperidone); histone deacetylase / GABA pathway (divalproex) | |
| Risperidone Long Acting | Risperidone Long Acting | Dartmouth-Hitchcock Medical Center | marketed | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor | |
| Aripiprazole or other oral antipsychotics | Aripiprazole or other oral antipsychotics | Otsuka Pharmaceutical Development & Commercialization, Inc. | marketed | Atypical antipsychotic | Dopamine D2 receptor (partial agonist); Serotonin 5-HT1A receptor (agonist) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Dopamine D2 receptor antagonist class)
- Assistance Publique - Hôpitaux de Paris · 1 drug in this class
- Idorsia Pharmaceuticals Ltd. · 1 drug in this class
- Otsuka Pharmaceutical Co., Ltd. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). ACT-539313 — Competitive Intelligence Brief. https://druglandscape.com/ci/act-539313. Accessed 2026-05-13.
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