Who are acetaminophen/codeine vs acetaminophen/oxycodone's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Naproxen Sodium Codeine, naproxen sodium codein, Nurofen Plus®.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

acetaminophen/codeine vs acetaminophen/oxycodone — Competitive Intelligence Brief

acetaminophen/codeine vs acetaminophen/oxycodone (acetaminophen/codeine vs acetaminophen/oxycodone) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid combination analgesic. Area: Pain Management.

marketed Opioid combination analgesic Mu-opioid receptor (oxycodone/codeine); COX inhibition (acetaminophen) Pain Management Small molecule Live · refreshed every 30 min

Target snapshot

acetaminophen/codeine vs acetaminophen/oxycodone (acetaminophen/codeine vs acetaminophen/oxycodone) — 59th Medical Wing. These are combination analgesics pairing acetaminophen (a non-opioid pain reliever) with either codeine or oxycodone (opioid agonists) to provide enhanced pain relief through complementary mechanisms.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
acetaminophen/codeine vs acetaminophen/oxycodone TARGET	acetaminophen/codeine vs acetaminophen/oxycodone	59th Medical Wing	marketed	Opioid combination analgesic	Mu-opioid receptor (oxycodone/codeine); COX inhibition (acetaminophen)
Naproxen Sodium Codeine	Naproxen Sodium Codeine	Istanbul Medeniyet University	marketed	NSAID + opioid combination analgesic	COX-1/COX-2 enzymes; mu opioid receptor
naproxen sodium codein	naproxen sodium codein	Diskapi Yildirim Beyazit Education and Research Hospital	marketed	NSAID + opioid combination analgesic	COX-1, COX-2, mu opioid receptor
Nurofen Plus®	Nurofen Plus®	Reckitt Benckiser LLC	phase 3	NSAID/opioid combination analgesic	COX-1/COX-2 (ibuprofen); mu opioid receptor (codeine)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid combination analgesic class)

59th Medical Wing · 1 drug in this class

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Cite this brief

Drug Landscape (2026). acetaminophen/codeine vs acetaminophen/oxycodone — Competitive Intelligence Brief. https://druglandscape.com/ci/acetaminophen-codeine-vs-acetaminophen-oxycodone. Accessed 2026-05-13.

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