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6MP — Competitive Intelligence Brief
marketed
Purine analog antimetabolite
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), inosine monophosphate dehydrogenase (IMPDH)
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
6MP (6MP) — South China Children's Leukemia Group. 6MP (6-mercaptopurine) is a purine analog that inhibits nucleotide synthesis and DNA replication, leading to cell death in rapidly dividing cells.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| 6MP TARGET | 6MP | South China Children's Leukemia Group | marketed | Purine analog antimetabolite | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), inosine monophosphate dehydrogenase (IMPDH) | |
| Fludarabine (Flud) | Fludarabine (Flud) | Technische Universität Dresden | marketed | Purine analog antimetabolite | Ribonucleotide reductase, DNA polymerase | |
| Fludarabine (Bayer) | Fludarabine (Bayer) | Chinese PLA General Hospital | marketed | Purine analog antimetabolite | Ribonucleotide reductase, DNA polymerase | |
| Experimental (fludarabine) | Experimental (fludarabine) | French Innovative Leukemia Organisation | phase 3 | Purine analog antimetabolite | Ribonucleotide reductase, DNA polymerase | |
| Mercaptopurine (Purinethol) | Mercaptopurine (Purinethol) | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | phase 3 | Purine analog antimetabolite | HGPRT (hypoxanthine-guanine phosphoribosyltransferase); inosinate dehydrogenase | |
| Nelarabine injection | Nelarabine injection | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | phase 3 | Purine analog antimetabolite | Ribonucleotide reductase; deoxyribonucleotide synthesis pathway | |
| Fludarabine mono | Fludarabine mono | German CLL Study Group | phase 3 | Purine analog antimetabolite | Ribonucleotide reductase; DNA polymerase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Purine analog antimetabolite class)
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · 1 drug in this class
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · 1 drug in this class
- Chinese PLA General Hospital · 1 drug in this class
- French Innovative Leukemia Organisation · 1 drug in this class
- German CLL Study Group · 1 drug in this class
- National Cancer Institute (NCI) · 1 drug in this class
- South China Children's Leukemia Group · 1 drug in this class
- Technische Universität Dresden · 1 drug in this class
- University of California, San Francisco · 1 drug in this class
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Cite this brief
Drug Landscape (2026). 6MP — Competitive Intelligence Brief. https://druglandscape.com/ci/6mp. Accessed 2026-05-13.
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