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5-fluorouracil,leucovorin,panitumumab — Competitive Intelligence Brief
phase 2
Chemotherapy combination with EGFR inhibitor
Thymidylate synthase (5-FU), EGFR (panitumumab)
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
5-fluorouracil,leucovorin,panitumumab (5-fluorouracil,leucovorin,panitumumab) — Fondazione IRCCS Istituto Nazionale dei Tumori, Milano. This combination uses 5-fluorouracil and leucovorin as chemotherapy agents to inhibit thymidylate synthase and enhance fluorouracil cytotoxicity, while panitumumab blocks EGFR signaling to prevent tumor cell growth and survival.
Comparator set (1 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| 5-fluorouracil,leucovorin,panitumumab TARGET | 5-fluorouracil,leucovorin,panitumumab | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | phase 2 | Chemotherapy combination with EGFR inhibitor | Thymidylate synthase (5-FU), EGFR (panitumumab) | |
| FOLFOX/ FOLFIRI with panitumumab | FOLFOX/ FOLFIRI with panitumumab | Dutch Colorectal Cancer Group | phase 3 | Chemotherapy combination with EGFR inhibitor | EGFR (panitumumab component) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Chemotherapy combination with EGFR inhibitor class)
- Dutch Colorectal Cancer Group · 1 drug in this class
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · 1 drug in this class
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Cite this brief
Drug Landscape (2026). 5-fluorouracil,leucovorin,panitumumab — Competitive Intelligence Brief. https://druglandscape.com/ci/5-fluorouracil-leucovorin-panitumumab. Accessed 2026-05-17.
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