Who are 5-flourouracil's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Xeloda, Fudr, Folic Acid, 5-Fluouracil, Capecitabine tablets, Irinotecan, 5FU, leucovorin.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-06-10 · How we verify

5-flourouracil — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

5-flourouracil (5-flourouracil) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: pyrimidine analog. Area: Oncology.

phase 2 pyrimidine analog thymidylate synthase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

5-flourouracil (5-flourouracil) — AstraZeneca. 5-fluorouracil is a thymidylate synthase inhibitor that disrupts DNA synthesis in rapidly dividing cancer cells.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
5-flourouracil TARGET	5-flourouracil	AstraZeneca	phase 2	pyrimidine analog	thymidylate synthase
Xeloda	capecitabine	Cheplapharm	marketed	Nucleoside Metabolic Inhibitor [EPC]	Thymidylate synthase	1998-01-01
Fudr	FLOXURIDINE		marketed	Antimetabolite [EPC]	Thymidylate synthase	1970-01-01
Folic Acid	FOLIC ACID	Pfizer	marketed	Vitamin C [EPC]	Thymidylate synthase	1946-01-01
5-Fluouracil	5-Fluouracil	Hoffmann-La Roche	marketed	Antimetabolite	Thymidylate synthase; RNA and DNA incorporation
Capecitabine tablets	Capecitabine tablets	UNICANCER	marketed	Fluoropyrimidine antimetabolite	Thymidylate synthase
Irinotecan, 5FU, leucovorin	Irinotecan, 5FU, leucovorin	Asan Medical Center	marketed	Chemotherapy combination (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (pyrimidine analog class)

AstraZeneca · 1 drug in this class
China Medical University, China · 1 drug in this class
Grupo Espanol de Tumores Neuroendocrinos · 1 drug in this class
Japan Clinical Oncology Group · 1 drug in this class
Servicio de Salud Metropolitano Sur Oriente · 1 drug in this class
UNICANCER · 1 drug in this class

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Cite this brief

Drug Landscape (2026). 5-flourouracil — Competitive Intelligence Brief. https://druglandscape.com/ci/5-flourouracil. Accessed 2026-06-10.

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