Who are ,4-diaminopyridine's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Firdapse, DALFAMPRIDINE, Sustained-release oral dalfampridine, SR-fampridine, TEV-48125, TETA 4HCL (60-<W108).

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Last reviewed 2026-06-10 · How we verify

,4-diaminopyridine — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

,4-diaminopyridine (,4-diaminopyridine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Potassium channel blocker. Area: Neurology.

phase 3 Potassium channel blocker Voltage-gated potassium channels (presynaptic) Neurology Small molecule Live · refreshed every 30 min

Target snapshot

,4-diaminopyridine (,4-diaminopyridine) — National Center for Research Resources (NCRR). 3,4-diaminopyridine blocks potassium channels on nerve terminals, prolonging action potentials and increasing acetylcholine release at the neuromuscular junction.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
,4-diaminopyridine TARGET	,4-diaminopyridine	National Center for Research Resources (NCRR)	phase 3	Potassium channel blocker	Voltage-gated potassium channels (presynaptic)
Firdapse	AMIFAMPRIDINE	Catalyst Pharms	marketed	Potassium Channel Blocker	Voltage-gated potassium channel	2018-01-01
DALFAMPRIDINE	DALFAMPRIDINE		marketed	Potassium Channel Blocker [EPC]		2010-01-01
Sustained-release oral dalfampridine	Sustained-release oral dalfampridine	Sheba Medical Center	marketed	Potassium channel blocker	Voltage-gated potassium channels (Kv channels)
SR-fampridine	SR-fampridine	University of Southern Denmark	marketed	Potassium channel blocker	Voltage-gated potassium channels
TEV-48125	TEV-48125	Otsuka Pharmaceutical Co., Ltd.	phase 3	sodium-activated potassium channel blocker	Nav1.5
TETA 4HCL (60-<W108)	TETA 4HCL (60-<W108)	Orphalan	phase 3	Potassium channel blocker	Potassium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Potassium channel blocker class)

Orphalan · 3 drugs in this class
Biogen · 2 drugs in this class
Essentialis, Inc. · 1 drug in this class
National Center for Research Resources (NCRR) · 1 drug in this class
Oregon Health and Science University · 1 drug in this class
Sheba Medical Center · 1 drug in this class
University of Southern Denmark · 1 drug in this class
D'Youville College · 1 drug in this class

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Cite this brief

Drug Landscape (2026). ,4-diaminopyridine — Competitive Intelligence Brief. https://druglandscape.com/ci/4-diaminopyridine. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing