{"id":"zopapogene-imadenovec-zopa","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":{"setId":"103db7f1-8540-4bea-935e-217d69e7aa01","title":"PAPZIMEOS (ZOPAPOGENE IMADENOVEC) INJECTION, SUSPENSION [PRECIGEN, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a genetically modified adenovirus designed to selectively replicate within cancer cells while expressing a transgene that enhances immune activation. The virus directly lyses tumor cells and releases tumor-associated antigens, while the transgene product stimulates local and systemic anti-tumor immunity. This combination of oncolytic activity and immunostimulation aims to overcome tumor immune evasion.","oneSentence":"Zopapogene imadenovec is an oncolytic adenovirus engineered to express an immunostimulatory transgene that replicates in tumor cells and triggers anti-tumor immune responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:50.705Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic melanoma"}]},"trialDetails":[{"nctId":"NCT06538480","phase":"PHASE4","title":"Zopa Retreatment and Vector Shedding in Adults With RRP","status":"RECRUITING","sponsor":"Precigen, Inc","startDate":"2024-07-11","conditions":"Recurrent Respiratory Papillomatosis, Papillomavirus Infection, Papillomaviridae","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Zopapogene imadenovec (Zopa)","genericName":"Zopapogene imadenovec (Zopa)","companyName":"Precigen, Inc","companyId":"precigen-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zopapogene imadenovec is an oncolytic adenovirus engineered to express an immunostimulatory transgene that replicates in tumor cells and triggers anti-tumor immune responses. Used for Metastatic melanoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}