{"id":"zomepirac","rwe":[],"tags":[{"label":"zomepirac","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin G/H synthase 2","category":"target"},{"label":"PTGS2","category":"gene"},{"label":"PTGS1","category":"gene"},{"label":"M01AB04","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"zomiperac","offLabel":[],"synonyms":["zomepirac sodium dihydrate","zomepirac","zomiperac","zomepirac sodium salt","zomepirac sodium"],"timeline":[],"aiSummary":"Zomiperac, also known as ZOMEPIRAC, is a small molecule drug that targets Prostaglandin G/H synthase 2. It belongs to the zomepirac drug class and was originally developed by an unknown entity. Unfortunately, there is limited information available on its commercial status, approved indications, and pharmacokinetic properties. As a result, its current owner, FDA approval status, half-life, bioavailability, generic manufacturers, and off-patent status remain unknown. Further research is necessary to determine its clinical utility and safety profile.","approvals":[],"brandName":"Zomiperac","ecosystem":[],"mechanism":{"target":"Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Cyclooxygenase","targets":[{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"},{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"}],"modality":"Small Molecule","drugClass":"zomepirac","explanation":"Imagine your body's pain and inflammation response like a fire. Prostaglandin G/H synthase 2 is like the fuel that keeps the fire burning. Zomiperac helps put out the fire by blocking the fuel supply, reducing pain and inflammation.","oneSentence":"Zomiperac works by inhibiting the enzyme Prostaglandin G/H synthase 2, which plays a key role in pain and inflammation.","technicalDetail":"Zomiperac exerts its analgesic and anti-inflammatory effects by competitively inhibiting the cyclooxygenase (COX) activity of Prostaglandin G/H synthase 2, thereby reducing the production of prostaglandins and thromboxanes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2871","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ZOMEPIRAC","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:16:31.889922","biosimilars":[],"competitors":[{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sulindac","drugSlug":"sulindac","fdaApproval":"1978-09-27","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolmetin","drugSlug":"tolmetin","fdaApproval":"1976-03-24","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"diclofenac","drugSlug":"diclofenac","fdaApproval":"1988-07-28","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"etodolac","drugSlug":"etodolac","fdaApproval":"1991-01-31","genericCount":25,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketorolac","drugSlug":"ketorolac","fdaApproval":"1989-11-30","patentExpiry":"Nov 24, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"zomepirac","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"indomethacin","brandName":"indomethacin","genericName":"indomethacin","approvalYear":"1965","relationship":"same-class"},{"drugId":"sulindac","brandName":"sulindac","genericName":"sulindac","approvalYear":"1978","relationship":"same-class"},{"drugId":"tolmetin","brandName":"tolmetin","genericName":"tolmetin","approvalYear":"1976","relationship":"same-class"},{"drugId":"diclofenac","brandName":"diclofenac","genericName":"diclofenac","approvalYear":"1988","relationship":"same-class"},{"drugId":"etodolac","brandName":"etodolac","genericName":"etodolac","approvalYear":"1991","relationship":"same-class"},{"drugId":"ketorolac","brandName":"ketorolac","genericName":"ketorolac","approvalYear":"1989","relationship":"same-class"},{"drugId":"aceclofenac","brandName":"aceclofenac","genericName":"aceclofenac","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"001603","UNII":"822G987U9J","CHEBI":"CHEBI:35859","INN_ID":"4054","RXNORM":"39994","UMLSCUI":"C0078840","ChEMBL_ID":"CHEMBL19490","KEGG_DRUG":"D06382","DRUGBANK_ID":"DB04828","PDB_CHEM_ID":" ZOM","PUBCHEM_CID":"5733","SNOMEDCT_US":"412341001","SECONDARY_CAS_RN":"64092-49-5","MESH_SUPPLEMENTAL_RECORD_UI":"C020549"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":231,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AB04","allCodes":["M01AB04"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"withdrawn","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"1980","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"enriching","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}