{"id":"zolpidem-pap-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Complex sleep behaviors"},{"rate":null,"effect":"PAP mask discomfort or skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Zolpidem is a sedative-hypnotic that binds to GABA-A receptors, increasing inhibitory neurotransmission and facilitating sleep onset and maintenance. PAP therapy (CPAP, BiPAP, or APAP) delivers pressurized air to prevent airway collapse in obstructive sleep apnea. This combination addresses both the sleep initiation/maintenance deficit and the underlying airway obstruction characteristic of sleep apnea.","oneSentence":"Zolpidem enhances GABAergic inhibition in the central nervous system to promote sleep, while PAP (positive airway pressure) therapy mechanically maintains airway patency during sleep.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:49.718Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia in patients with obstructive sleep apnea on PAP therapy"},{"name":"Sleep maintenance disorder in sleep apnea patients"}]},"trialDetails":[{"nctId":"NCT04118387","phase":"PHASE4","title":"Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2021-01-07","conditions":"Sleep Disordered Breathing, Able Bodied","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Zolpidem + PAP therapy","genericName":"Zolpidem + PAP therapy","companyName":"VA Office of Research and Development","companyId":"va-office-of-research-and-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zolpidem enhances GABAergic inhibition in the central nervous system to promote sleep, while PAP (positive airway pressure) therapy mechanically maintains airway patency during sleep. Used for Insomnia in patients with obstructive sleep apnea on PAP therapy, Sleep maintenance disorder in sleep apnea patients.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}