{"id":"zoloft-tablets","safety":{"commonSideEffects":[{"rate":"20-26%","effect":"Nausea"},{"rate":"12-18%","effect":"Diarrhea"},{"rate":"13-24%","effect":"Headache"},{"rate":"8-11%","effect":"Tremor"},{"rate":"15-28%","effect":"Insomnia"},{"rate":"15-25%","effect":"Sexual dysfunction"},{"rate":"5-13%","effect":"Somnolence"},{"rate":"9-16%","effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter protein, preventing the reabsorption of serotonin from the synaptic cleft back into presynaptic neurons. This increases serotonin concentration in the synapse, enhancing neurotransmission and improving mood regulation. The mechanism is thought to underlie its efficacy in treating depression, anxiety disorders, and related conditions.","oneSentence":"Zoloft selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:48.175Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Obsessive-compulsive disorder"},{"name":"Panic disorder"},{"name":"Posttraumatic stress disorder"},{"name":"Social anxiety disorder"},{"name":"Premenstrual dysphoric disorder"}]},"trialDetails":[{"nctId":"NCT00262470","phase":"PHASE1, PHASE2","title":"Treatment of Orthostatic Intolerance","status":"ACTIVE_NOT_RECRUITING","sponsor":"Satish R. Raj","startDate":"1997-04","conditions":"Tachycardia, Chronic Orthostatic Intolerance","enrollment":150},{"nctId":"NCT06698666","phase":"PHASE3","title":"Efficacy of Statins Among Major Depressive Disorder","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2022-10-01","conditions":"Major Depressive Disorder, MDD","enrollment":145},{"nctId":"NCT06001021","phase":"NA","title":"Cognitive Behavioral Couple Therapy for Perinatal Distress","status":"COMPLETED","sponsor":"Sameera Shafiq","startDate":"2023-08-15","conditions":"Perinatal Depression, Perinatal Anxiety","enrollment":96},{"nctId":"NCT02813447","phase":"NA","title":"Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)","status":"TERMINATED","sponsor":"Duke University","startDate":"2016-08","conditions":"COPD, Anxiety, Depression","enrollment":13},{"nctId":"NCT04124614","phase":"PHASE3","title":"Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSD","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2019-10-17","conditions":"Post Traumatic Stress Disorder","enrollment":450},{"nctId":"NCT02777372","phase":"PHASE4","title":"Stress & Premenstrual Symptoms Study","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2016-04-01","conditions":"PMDD, Stress, Mood","enrollment":84},{"nctId":"NCT06704594","phase":"PHASE4","title":"Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2025-05-14","conditions":"Premenstrual Dysphoric Disorder (PMDD)","enrollment":288},{"nctId":"NCT04174170","phase":"PHASE3","title":"Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress Disorder","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2019-10-30","conditions":"Post Traumatic Stress Disorder","enrollment":591},{"nctId":"NCT06840379","phase":"NA","title":"Effect of Sertraline on Inflammation in Hemodialysis Patients with Depression: a Randomized Controlled Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nishtar Medical University","startDate":"2024-10-15","conditions":"Inflamation, Hemodialysis, End Stage Renal Disease on Hemodialysis (Diagnosis)","enrollment":62},{"nctId":"NCT06827431","phase":"PHASE3","title":"The Research of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With Depression","status":"NOT_YET_RECRUITING","sponsor":"CSPC ZhongQi Pharmaceutical Technology Co., Ltd.","startDate":"2025-02-14","conditions":"Major Depressive Disorder (MDD)","enrollment":770},{"nctId":"NCT06778824","phase":"NA","title":"Neuroregulators for the Treatment of Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.","status":"RECRUITING","sponsor":"Hualien Tzu Chi General Hospital","startDate":"2024-04-02","conditions":"Gut-Brain Disorders, GERD Without Erosive Esophagitis","enrollment":610},{"nctId":"NCT06725771","phase":"NA","title":"A Non-randomized Controlled Trial Was Conducted to Observe the Improvement in the Level of HAMA in Patients With Generalized Anxiety Disorder During the 6-week Period of Oral Treatment With Chaihu Jia Longgu Muli Tang (Bupleurum Plus Dragon Bone and Oyster Shell Decoction) Combined With Sertraline.","status":"COMPLETED","sponsor":"Lin Xiaoqian","startDate":"2022-09-01","conditions":"Generalised Anxiety Disorder","enrollment":205},{"nctId":"NCT06580249","phase":"NA","title":"Efficacy and Mechanism of rTMS on the Symptoms of Pleasure Deficit in Adolescent Depression","status":"RECRUITING","sponsor":"Xijing Hospital","startDate":"2024-09-05","conditions":"Depression","enrollment":44},{"nctId":"NCT00836667","phase":"PHASE1","title":"Sertraline Hydrochloride 100 mg Tablets, Fed","status":"COMPLETED","sponsor":"Teva Pharmaceuticals USA","startDate":"2002-03","conditions":"Healthy","enrollment":18},{"nctId":"NCT00836849","phase":"PHASE1","title":"Sertraline Hydrochloride 100 mg Tablets, Fasting","status":"COMPLETED","sponsor":"Teva Pharmaceuticals USA","startDate":"2002-03","conditions":"Healthy","enrollment":24},{"nctId":"NCT00648856","phase":"PHASE1","title":"Food Study of Sertraline Hydrochloride Tablets 100 mg and Zoloft® Tablets 100 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2002-12","conditions":"Healthy","enrollment":21},{"nctId":"NCT00650325","phase":"PHASE1","title":"Study of Sertraline Hydrochloride Tablets 100 mg and Zoloft® Tablets 100 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2002-11","conditions":"Healthy","enrollment":49},{"nctId":"NCT06358014","phase":"NA","title":"Assessment of the Improvement in Cognitive Levels of Postmenopausal Depression Patients by Estrogen","status":"RECRUITING","sponsor":"Xiao Wang","startDate":"2023-05-12","conditions":"Postmenopausal Depression, Estrogen","enrollment":40},{"nctId":"NCT05189977","phase":"PHASE1","title":"A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline","status":"TERMINATED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2022-09-07","conditions":"Post-traumatic Stress Disorder (PTSD)","enrollment":34},{"nctId":"NCT04476030","phase":"PHASE3","title":"A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder","status":"COMPLETED","sponsor":"Biogen","startDate":"2020-11-09","conditions":"Depressive Disorder, Major","enrollment":440},{"nctId":"NCT03538691","phase":"PHASE3","title":"A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2018-07-13","conditions":"Major Depressive Disorder","enrollment":1149},{"nctId":"NCT06025474","phase":"PHASE3","title":"Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome","status":"UNKNOWN","sponsor":"Federico II University","startDate":"2023-01-01","conditions":"Burning Mouth Syndrome","enrollment":203},{"nctId":"NCT05923021","phase":"NA","title":"Moderate Depressive Disorder With Cheek Acupuncture","status":"UNKNOWN","sponsor":"The First Affiliated Hospital of Zhejiang Chinese Medical University","startDate":"2023-07-01","conditions":"Acupuncture, Depression","enrollment":126},{"nctId":"NCT05737511","phase":"PHASE4","title":"Efficacy of Hydroxyzine for Patients With Panic Disorder","status":"NOT_YET_RECRUITING","sponsor":"Sultan Qaboos University","startDate":"2023-12-30","conditions":"Panic Disorder","enrollment":80},{"nctId":"NCT05341843","phase":"PHASE2","title":"Sertraline Effect in Uremic Pruritis","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-05-01","conditions":"Uremic Pruritis","enrollment":60},{"nctId":"NCT02452983","phase":"PHASE1","title":"Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome","status":"TERMINATED","sponsor":"Gustavo Rivero","startDate":"2015-05","conditions":"Myelodysplastic Syndromes","enrollment":14},{"nctId":"NCT03033069","phase":"PHASE2","title":"A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2017-01-26","conditions":"Stress Disorders, Post-Traumatic","enrollment":336},{"nctId":"NCT05148169","phase":"PHASE4","title":"A Pilot Study on Effect of add-on Sulforaphane to SSRIs and Application of Niacin Skin Flush Response Test in Major Depressive Disorder","status":"UNKNOWN","sponsor":"Shanghai Mental Health Center","startDate":"2020-01-01","conditions":"Major Depressive Disorder","enrollment":150},{"nctId":"NCT02088697","phase":"PHASE1","title":"A Bioequivalence Study of ASC-01 Placebo (Aripiprazole 0 mg/Sertraline 100 mg) and Sertraline Tablet in Healthy Male Subjects","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2013-12","conditions":"Healthy Volunteers","enrollment":50},{"nctId":"NCT04071639","phase":"PHASE1","title":"Symptomatic Therapy for Patients With Huntington's Disease","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2020-03-12","conditions":"Huntington Disease","enrollment":60},{"nctId":"NCT00636246","phase":"PHASE2","title":"A Comparison of Sertraline-reboxetine Combination Therapy Versus Sertraline or Reboxetine Monotherapy in the Treatment of Major Depression.","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2004-06","conditions":"Depressive Disorder, Major","enrollment":510},{"nctId":"NCT00605813","phase":"","title":"Special Investigation Of Long Term Use Of Sertraline.","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2007-09","conditions":"Depression, Panic Disorder","enrollment":542},{"nctId":"NCT00605865","phase":"","title":"Drug Use Investigation of Jzoloft.","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2007-04","conditions":"Panic Disorder, Depression","enrollment":2272},{"nctId":"NCT00605917","phase":"","title":"Special Investigation Of J Zoloft For Panic Disorder Patients","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2007-04","conditions":"Panic Disorder","enrollment":997},{"nctId":"NCT00644982","phase":"PHASE4","title":"A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2002-10","conditions":"Depressive Disorder, Major","enrollment":163},{"nctId":"NCT00677352","phase":"PHASE4","title":"A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2008-05","conditions":"Panic Disorder","enrollment":321},{"nctId":"NCT01699724","phase":"PHASE1","title":"Bioequivalence Of Zoloft ODT To Jzoloft In Healthy Japanese Subjects","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2012-09","conditions":"Healthy","enrollment":30},{"nctId":"NCT01607593","phase":"","title":"A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2012-08","conditions":"Posttraumatic Stress Disorder","enrollment":123},{"nctId":"NCT01235195","phase":"PHASE1","title":"A Study Comparing the Drug Exposure in Humans After Administration of a 50 mg Tablet of Sertraline Hydrochloride as Compared to a 50 mg Capsule of Sertraline Hydrochloride Under Fasted (Nonfed) Conditions","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2010-11","conditions":"Healthy","enrollment":30},{"nctId":"NCT03711708","phase":"PHASE4","title":"Relative Bioavailability Study of Zoloft Oral Solution to Zoloft Tablets","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2018-11-06","conditions":"Healthy","enrollment":36},{"nctId":"NCT03002012","phase":"PHASE3","title":"Cryptococcal Antigen Screening Plus Sertraline","status":"TERMINATED","sponsor":"University of Minnesota","startDate":"2017-11-15","conditions":"Cryptococcosis, Cryptococcal Infections, AIDS-Related Opportunistic Infections","enrollment":22},{"nctId":"NCT02358343","phase":"PHASE3","title":"A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND}","status":"COMPLETED","sponsor":"University of Washington","startDate":"2015-03-23","conditions":"Depression, End Stage Renal Disease","enrollment":184},{"nctId":"NCT00386243","phase":"NA","title":"Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2007-12","conditions":"Low Back Pain, Pain, Pain, Intractable","enrollment":242},{"nctId":"NCT01155531","phase":"PHASE1","title":"Safety & Tolerability of a Combination of Antidepressant and Peptic Ulcer Drug in Overweight Healthy Subjects","status":"COMPLETED","sponsor":"Theracos","startDate":"2010-05","conditions":"Obesity","enrollment":40},{"nctId":"NCT01360866","phase":"PHASE3","title":"Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2011-10","conditions":"Depressive Disorder, Depression, Depressive Disorder, Major","enrollment":2944},{"nctId":"NCT02235064","phase":"NA","title":"Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression","status":"TERMINATED","sponsor":"The Cooper Health System","startDate":"2014-07","conditions":"Depression, Postpartum","enrollment":2},{"nctId":"NCT00946998","phase":"PHASE3","title":"Chronic Kidney Disease Antidepressant Sertraline Trial","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2010-02-08","conditions":"Chronic Kidney Disease, Depression","enrollment":201},{"nctId":"NCT00602849","phase":"NA","title":"Bioequivalency Study of Sertraline Under Fasting Conditions","status":"COMPLETED","sponsor":"Roxane Laboratories","startDate":"2003-06","conditions":"Depression","enrollment":38},{"nctId":"NCT00601588","phase":"NA","title":"Bioequivalency Study of Sertraline Under Fed Conditions","status":"COMPLETED","sponsor":"Roxane Laboratories","startDate":"2003-06","conditions":"Depression","enrollment":43},{"nctId":"NCT02178696","phase":"PHASE4","title":"Predictors of Antidepressant Response","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2011-01","conditions":"Depression","enrollment":44},{"nctId":"NCT02641652","phase":"PHASE4","title":"A Randomized Controlled Trial of Sertraline in Paroxysmal Arterial Hypertension","status":"UNKNOWN","sponsor":"University Hospital Olomouc","startDate":"2017-11","conditions":"Hypertension","enrollment":136},{"nctId":"NCT02400346","phase":"PHASE3","title":"Evaluation of the Safety of Adjunct Brexpiprazole in Elderly Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Treatment","status":"COMPLETED","sponsor":"H. Lundbeck A/S","startDate":"2015-03","conditions":"Major Depression Disorder","enrollment":132},{"nctId":"NCT01838681","phase":"PHASE3","title":"Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment","status":"COMPLETED","sponsor":"H. Lundbeck A/S","startDate":"2013-06","conditions":"Major Depressive Disorder","enrollment":1986},{"nctId":"NCT00078767","phase":"PHASE3","title":"Pharmacologic Treatment of PTSD in Sexually Abused Children","status":"COMPLETED","sponsor":"Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)","startDate":"2001-04","conditions":"Stress Disorders, Post-Traumatic","enrollment":24},{"nctId":"NCT01987960","phase":"PHASE3","title":"Brexpiprazole as an Adjunctive Treatment to Paroxetine or Sertraline in Adult Patients Suffering From Post-traumatic Stress Disorder (PTSD)","status":"TERMINATED","sponsor":"H. Lundbeck A/S","startDate":"2013-12","conditions":"Post-traumatic Stress Disorder, PTSD","enrollment":417},{"nctId":"NCT01178671","phase":"PHASE4","title":"Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial","status":"COMPLETED","sponsor":"Research Foundation for Mental Hygiene, Inc.","startDate":"2010-07","conditions":"Posttraumatic Stress Disorder","enrollment":38},{"nctId":"NCT01214382","phase":"PHASE3","title":"Pharmacokinetic Properties of Sertraline Before and After Gastric Bypass Surgery","status":"COMPLETED","sponsor":"North Dakota State University","startDate":"2010-10","conditions":"Roux en Y Gastric Bypass Surgery","enrollment":31},{"nctId":"NCT00797966","phase":"PHASE2","title":"Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2009-05","conditions":"Major Depressive Disorder","enrollment":850},{"nctId":"NCT00704379","phase":"PHASE2, PHASE3","title":"Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2008-06","conditions":"Traumatic Brain Injury","enrollment":94},{"nctId":"NCT01669304","phase":"PHASE1","title":"Verapamil vs. Sertraline for Vestibular Migraine & Chronic Subjective Dizziness","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2012-08","conditions":"Vestibular Migraine, Chronic Subjective Dizziness","enrollment":32},{"nctId":"NCT01569685","phase":"PHASE4","title":"The Treatment of Traumatised Refugees With Sertraline Versus Venlafaxine in Combination With Psychotherapy","status":"COMPLETED","sponsor":"Charlotte Sonne","startDate":"2012-04","conditions":"Post Traumatic Stress Disorder, Depression","enrollment":207},{"nctId":"NCT02175602","phase":"PHASE1","title":"Study of Drug Combination on Pharmacokinetics in Healthy Volunteers","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"2014-06","conditions":"Hepatitis C Infection","enrollment":41},{"nctId":"NCT00177424","phase":"PHASE4","title":"Sertraline for Preventing Post-stroke Depression and Improving Rehabilitation Outcomes","status":"TERMINATED","sponsor":"University of Pittsburgh","startDate":"2004-07","conditions":"Cerebrovascular Accident, Depression","enrollment":154},{"nctId":"NCT00510822","phase":"PHASE2","title":"Cimicoxib for the Treatment of Major Depression (SECIM)","status":"COMPLETED","sponsor":"Affectis Pharmaceuticals AG","startDate":"2007-10","conditions":"Major Depression","enrollment":169},{"nctId":"NCT00056472","phase":"PHASE3","title":"Study of Pharmacotherapy of Psychotic Depression","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2003-01","conditions":"Major Depressive Disorder With Psychotic Features","enrollment":259},{"nctId":"NCT00299611","phase":"PHASE2, PHASE3","title":"Augmentation Study of Levetiracetam in Obsessive Compulsive Disorder","status":"TERMINATED","sponsor":"Duke University","startDate":"2005-11","conditions":"Obsessive-Compulsive Disorder","enrollment":12},{"nctId":"NCT00944996","phase":"NA","title":"Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression","status":"COMPLETED","sponsor":"Tirat Carmel Mental Health Center","startDate":"2009-06","conditions":"Major Depression","enrollment":100},{"nctId":"NCT00208117","phase":"PHASE1","title":"A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease","status":"TERMINATED","sponsor":"New York State Psychiatric Institute","startDate":"2005-04","conditions":"Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)","enrollment":7},{"nctId":"NCT00857584","phase":"PHASE3","title":"Quetiapine XR Versus Sertraline in Acute Bipolar Depression as add-on Therapy","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2009-05","conditions":"Bipolar Disorder, Bipolar Depression","enrollment":27},{"nctId":"NCT01267396","phase":"PHASE1","title":"Bioequivalence Study of Sertraline Hydrochloride Tablets 100 mg Under Fasting Conditions","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2006-09","conditions":"Healthy","enrollment":32},{"nctId":"NCT01267383","phase":"PHASE1","title":"Bioequivalence Study of Sertraline Hydrochloride Tablets 100 mg in Fed Conditions","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2006-09","conditions":"Healthy","enrollment":32},{"nctId":"NCT00864019","phase":"PHASE1","title":"A Relative Bioavailability Study of Sertraline HCl 100 mg Tablets Under Non-fasting Conditions","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2004-08","conditions":"Healthy","enrollment":30},{"nctId":"NCT00864344","phase":"PHASE1","title":"A Relative Bioavailability Study of Sertraline HCl 100 mg Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2004-08","conditions":"Healthy","enrollment":30},{"nctId":"NCT00946036","phase":"PHASE1","title":"Bioequivalence Study of Sertraline 100 mg Tablet and ZOLOFT Following a 100 mg Dose in Healthy Subjects Under Fed Conditions","status":"COMPLETED","sponsor":"Torrent Pharmaceuticals Limited","startDate":"","conditions":"Healthy","enrollment":""},{"nctId":"NCT00944242","phase":"PHASE1","title":"Bioequivalence Study of Sertraline 100 mg Tablet and ZOLOFT Following a 100 mg Dose in Healthy Subjects Under Fasting Conditions","status":"COMPLETED","sponsor":"Torrent Pharmaceuticals Limited","startDate":"","conditions":"Healthy","enrollment":""},{"nctId":"NCT00778973","phase":"NA","title":"Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fed Conditions","status":"COMPLETED","sponsor":"Ranbaxy Laboratories Limited","startDate":"2005-08","conditions":"Healthy","enrollment":36},{"nctId":"NCT00779350","phase":"NA","title":"Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Ranbaxy Laboratories Limited","startDate":"2005-08","conditions":"Healthy","enrollment":36}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"PRODUCT DOSE OMISSION"},{"count":1,"reaction":"SURGERY"},{"count":1,"reaction":"TRANSIENT ISCHAEMIC ATTACK"}],"_approvalHistory":[],"publicationCount":59,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Zoloft tablets","genericName":"Zoloft tablets","companyName":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","companyId":"pfizer-s-upjohn-has-merged-with-mylan-to-form-viatris-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zoloft selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. Used for Major depressive disorder, Obsessive-compulsive disorder, Panic disorder.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}