{"id":"zofran-inj-zofran-tab","safety":{"commonSideEffects":[{"rate":"9-27%","effect":"Headache"},{"rate":"5-25%","effect":"Constipation"},{"rate":"3-15%","effect":"Diarrhea"},{"rate":"5-13%","effect":"Fatigue"},{"rate":"4-13%","effect":"Dizziness"},{"rate":"2-8%","effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ondansetron is a selective 5-HT3 receptor antagonist that works centrally and peripherally to inhibit signals that trigger the vomiting reflex. It is particularly effective against chemotherapy-induced nausea and vomiting (CINV) and post-operative nausea and vomiting (PONV) by blocking serotonin signaling in the chemoreceptor trigger zone and on vagal afferent fibers in the gastrointestinal tract.","oneSentence":"Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:45.154Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Post-operative nausea and vomiting (PONV)"},{"name":"Radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT06153602","phase":"NA","title":"Effectiveness of Nalbuphine as an Adjuvant to Subarachnoid Block on Postoperative Analgesia in TURP Surgery","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2023-12-07","conditions":"Transurethral Resection of Prostate","enrollment":80},{"nctId":"NCT01659775","phase":"PHASE4","title":"Phase 4 Trial to Evaluate the Efficacy and Safety of Sancuso Patch in Chemotherapy-induced Nausea and Vomiting Associated With the Administration of Highly Emetogenic Chemotherapy (HEC)","status":"COMPLETED","sponsor":"LG Life Sciences","startDate":"2011-08","conditions":"Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV)","enrollment":389}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Zofran inj.+Zofran tab.","genericName":"Zofran inj.+Zofran tab.","companyName":"LG Life Sciences","companyId":"lg-life-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting. Used for Chemotherapy-induced nausea and vomiting (CINV), Post-operative nausea and vomiting (PONV), Radiation-induced nausea and vomiting.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}