{"id":"zofenopril","rwe":[{"pmid":"41536241","year":"2026","title":"Effect of the ACE inhibitor Zofenopril on the Oxidative Status of the Eye in Animals with Experimental Glaucoma.","finding":"","journal":"Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti","studyType":"Clinical Study"},{"pmid":"41536196","year":"2026","title":"Protective Effects of Zofenopril, Thymoquinone and Their Co-Administration Against Cyclophosphamide-Induced Ovarian Toxicity in Rats.","finding":"","journal":"Journal of biochemical and molecular toxicology","studyType":"Clinical Study"},{"pmid":"41532630","year":"2025","title":"Vasoactive Effects of Chronic Treatment with ACE Inhibitor Zofenopril in Zucker Obese Diabetic Rats: The Role of Nitroso and Sul?de Signalization.","finding":"","journal":"Physiological research","studyType":"Clinical Study"},{"pmid":"40884746","year":"2025","title":"Cardioprotective effect of zofenopril, thymoquinone and their combination in cyclophosphamide-induced cardiotoxicity in rats.","finding":"","journal":"Human & experimental toxicology","studyType":"Clinical Study"},{"pmid":"40093946","year":"2025","title":"Effects of Zofenopril and Thymoquinone in Cyclophosphamide-Induced Urotoxicity and Nephrotoxicity in Rats; The Value of Their Anti-Inflammatory and Antioxidant Properties.","finding":"","journal":"Journal of inflammation research","studyType":"Clinical Study"}],"tags":[{"label":"zofenopril","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Angiotensin-converting enzyme","category":"target"},{"label":"ACE","category":"gene"},{"label":"C09AA15","category":"atc"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"},{"label":"Angiotensin-Converting Enzyme Inhibitors","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protease Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":222.294,"date":"","count":134,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 134 times (LLR=222)"},{"llr":97.154,"date":"","count":53,"signal":"Bradycardia","source":"DrugCentral FAERS","actionTaken":"Reported 53 times (LLR=97)"},{"llr":72.313,"date":"","count":13,"signal":"Hyponatraemic syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=72)"},{"llr":56.295,"date":"","count":21,"signal":"Hypertensive crisis","source":"DrugCentral FAERS","actionTaken":"Reported 21 times (LLR=56)"},{"llr":50.134,"date":"","count":13,"signal":"Vascular stent thrombosis","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=50)"},{"llr":44.102,"date":"","count":37,"signal":"Syncope","source":"DrugCentral FAERS","actionTaken":"Reported 37 times (LLR=44)"},{"llr":43.374,"date":"","count":6,"signal":"Hallucination, gustatory","source":"DrugCentral FAERS","actionTaken":"Reported 6 times (LLR=43)"},{"llr":40.223,"date":"","count":10,"signal":"Muscle contracture","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=40)"},{"llr":39.878,"date":"","count":27,"signal":"Dry mouth","source":"DrugCentral FAERS","actionTaken":"Reported 27 times (LLR=40)"}],"commonSideEffects":[{"effect":"Drug interaction","drugRate":"LLR 222","severity":"common"},{"effect":"Bradycardia","drugRate":"LLR 97","severity":"common"},{"effect":"Hyponatraemic syndrome","drugRate":"LLR 72","severity":"common"},{"effect":"Hypertensive crisis","drugRate":"LLR 56","severity":"common"},{"effect":"Vascular stent thrombosis","drugRate":"LLR 50","severity":"common"},{"effect":"Syncope","drugRate":"LLR 44","severity":"common"},{"effect":"Hallucination, gustatory","drugRate":"LLR 43","severity":"common"},{"effect":"Muscle contracture","drugRate":"LLR 40","severity":"common"},{"effect":"Dry mouth","drugRate":"LLR 40","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"sq. 26,991","offLabel":[],"synonyms":["zofenopril","zofenopril calcium","SQ-26991","SQ. 26,991","zofenopril potassium"],"timeline":[],"approvals":[],"brandName":"Sq. 26,991","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"target":"Angiotensin-converting enzyme","targets":[{"gene":"ACE","source":"DrugCentral","target":"Angiotensin-converting enzyme","protein":"Angiotensin-converting enzyme"}],"modality":"Small Molecule","drugClass":"zofenopril","explanation":"Think of the renin-angiotensin-aldosterone system like a plumbing system in your body. 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