{"id":"zocular-eyelid-system-treatment","safety":{"commonSideEffects":[{"rate":null,"effect":"Eyelid erythema"},{"rate":null,"effect":"Transient discomfort during treatment"},{"rate":null,"effect":"Mild eyelid edema"}]},"_chembl":{"chemblId":"CHEMBL2108729","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The device uses localized heating and mechanical pulsation to warm the lipid secretions within meibomian glands, reducing their viscosity and allowing them to be expressed more effectively. This restores the lipid layer of the tear film, which is essential for tear stability and reducing evaporative dry eye symptoms. By clearing gland obstruction and improving meibum quality, the treatment addresses the underlying pathophysiology of meibomian gland dysfunction.","oneSentence":"The Zocular Eyelid System Treatment is a thermal pulsation device that applies controlled heat and pressure to the eyelids to liquefy and express meibum from blocked meibomian glands.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:16:37.247Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Meibomian gland dysfunction"},{"name":"Evaporative dry eye disease"}]},"trialDetails":[{"nctId":"NCT05990712","phase":"PHASE4","title":"The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers","status":"UNKNOWN","sponsor":"Uptown Eye Specialists","startDate":"2023-09-01","conditions":"Dry Eye, Dry Eye Syndromes, Cataract","enrollment":68},{"nctId":"NCT03968731","phase":"NA","title":"Meibomian Gland Dysfunction Management With ZEST Protocol","status":"COMPLETED","sponsor":"University of the Incarnate Word","startDate":"2019-06-10","conditions":"Meibomian Gland Dysfunction, Dry Eye Syndromes, Ocular Surface Disease","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ZEST"],"phase":"marketed","status":"active","brandName":"Zocular Eyelid System Treatment","genericName":"Zocular Eyelid System Treatment","companyName":"Uptown Eye Specialists","companyId":"uptown-eye-specialists","modality":"Small molecule","firstApprovalDate":"","aiSummary":"The Zocular Eyelid System Treatment is a thermal pulsation device that applies controlled heat and pressure to the eyelids to liquefy and express meibum from blocked meibomian glands. Used for Meibomian gland dysfunction, Evaporative dry eye disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}