{"id":"zinostatin","rwe":[{"pmid":"39926261","year":"2025","title":"Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients.","finding":"","journal":"Therapeutic advances in medical oncology","studyType":"Clinical Study"},{"pmid":"26402250","year":"2015","title":"Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects.","finding":"","journal":"Expert review of anticancer therapy","studyType":"Clinical Study"},{"pmid":"24606040","year":"2014","title":"Recent advances in active hepatic targeting drug delivery system.","finding":"","journal":"Current drug targets","studyType":"Clinical Study"},{"pmid":"22187203","year":"2012","title":"A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma.","finding":"","journal":"Investigational new drugs","studyType":"Clinical Study"},{"pmid":"19864035","year":"2009","title":"Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: a randomized phase III trial.","finding":"","journal":"Journal of hepatology","studyType":"Clinical Study"}],"tags":[{"label":"zinostatin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antibiotics, Antineoplastic","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Cytotoxins","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Noxae","category":"pharmacology"},{"label":"Nucleic Acid Synthesis Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"vinostatin","offLabel":[],"synonyms":["zinostatin","holoneocarzinostatin","neocarcinostatin","vinostatin","neocarzinostatin"],"timeline":[],"approvals":[],"brandName":"Vinostatin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"zinostatin","explanation":"Imagine your body's cells are like a city with too many people. Zinostatin helps to slow down the growth of new buildings (cells) and eventually causes some of the old buildings to be torn down (apoptosis), which can help to control the spread of cancer.","oneSentence":"Zinostatin works by inhibiting cell growth and inducing apoptosis in cancer cells.","technicalDetail":"Zinostatin is a type of enzyme inhibitor that targets the cell cycle, specifically the G2/M phase, to induce apoptosis and inhibit cell proliferation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4108","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ZINOSTATIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ZINOSTATIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:16:10.499828","biosimilars":[],"competitors":[],"genericName":"zinostatin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07024446","phase":"","title":"Comparison of Cardiovascular Risks Between Hip Fracture Surgery With Continued DAPT（Dual Antiplatelet Therapy ） Within 6 Weeks vs After 6 Weeks Post-PCI（Percutaneous Coronary Intervention）: A Prospective Observational Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"Fujian Medical University Union Hospital","startDate":"2025-07-01","conditions":["PCI Patients","DAPT(Dual Antiplatelet Therapy)","Hip Fracture Surgeries"],"enrollment":50,"completionDate":"2027-07-01"},{"nctId":"NCT06201806","phase":"NA","title":"To Compare Influence of Breakfast With and Without Sweeteners on Postprandial Glycemic Response and Appetite-Satiety Sensation in Subjects With Type 1 Diabetes","status":"COMPLETED","sponsor":"University of Chile","startDate":"2019-01-02","conditions":["Diabetes Mellitus, Type 1"],"enrollment":32,"completionDate":"2022-12-20"},{"nctId":"NCT04129762","phase":"NA","title":"Effect of a Diet Without Non-caloric Sweeteners on Gastrointestinal Symptoms in Patients With IBS and Dyspepsia","status":"UNKNOWN","sponsor":"Hospital General de Mexico","startDate":"2019-07-17","conditions":["IBS - Irritable Bowel Syndrome","Functional Gastrointestinal Disorders"],"enrollment":140,"completionDate":"2020-12-31"},{"nctId":"NCT01327521","phase":"PHASE3","title":"Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma","status":"WITHDRAWN","sponsor":"Albert Koong","startDate":"2011-02","conditions":["Carcinoma, Hepatocellular"],"enrollment":0,"completionDate":""},{"nctId":"NCT01094418","phase":"","title":"Electrodiagnostic Parameters in Patients With Impaired Glucose Tolerance and Diabetes Mellitus","status":"COMPLETED","sponsor":"The Catholic University of Korea","startDate":"2009-06","conditions":["Impaired Glucose Tolerance","Peripheral Polyneuropathy","DM"],"enrollment":150,"completionDate":"2010-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"PP082U6W1L","INN_ID":"4458","UMLSCUI":"C0027597","ChEMBL_ID":"CHEMBL3989835","KEGG_DRUG":"D02046","DRUGBANK_ID":"DB04408","PDB_CHEM_ID":"CHR","PUBCHEM_CID":"57125363","MESH_DESCRIPTOR_UI":"D009353"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":41,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"39926261","title":"Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients.","journal":"Therapeutic advances in medical oncology"},{"date":"2015","pmid":"26402250","title":"Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects.","journal":"Expert review of anticancer therapy"},{"date":"2014 Jun","pmid":"24606040","title":"Recent advances in active hepatic targeting drug delivery system.","journal":"Current drug targets"},{"date":"2012 Oct","pmid":"22187203","title":"A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma.","journal":"Investigational new drugs"},{"date":"2009 Dec","pmid":"19864035","title":"Transarterial chemotherapy alone versus transarterial chemoembolization for hepatocellular carcinoma: a randomized phase III trial.","journal":"Journal of hepatology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vinostatin is a small molecule with the synonyms HOLONEOCARZINOSTATIN, NEOCARZINOSTATIN, NSC-157365, NSC-69856, ZINOSTATIN, and ZINOSTATIN. 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