{"id":"zinc-l-carnosine","safety":{"commonSideEffects":[{"rate":null,"effect":"Generally well-tolerated with minimal adverse events"}]},"_chembl":{"chemblId":"CHEMBL242948","moleculeType":"Small molecule","molecularWeight":"226.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Zinc-l-carnosine is a dipeptide chelate compound that combines zinc with l-carnosine to provide cytoprotective effects in the gastrointestinal tract. It works by scavenging reactive oxygen species, stabilizing mast cells, and promoting mucosal regeneration and barrier function. The compound has been shown to reduce inflammation and support healing of damaged gastric and intestinal tissue.","oneSentence":"Zinc-l-carnosine forms a chelate complex that protects and promotes healing of the gastrointestinal mucosa by reducing oxidative stress and enhancing mucosal defense mechanisms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:16:34.579Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastric ulcer"},{"name":"Gastritis"},{"name":"Gastrointestinal mucosal damage and inflammation"}]},"trialDetails":[{"nctId":"NCT07379645","phase":"NA","title":"A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes","status":"NOT_YET_RECRUITING","sponsor":"NutriScience Innovations, LLC","startDate":"2026-01-15","conditions":"Heartburn","enrollment":50},{"nctId":"NCT06678997","phase":"NA","title":"Polaprezinc (Zinc L-carnosine) in Infants With Gastroesophageal Reflux","status":"NOT_YET_RECRUITING","sponsor":"University of Roma La Sapienza","startDate":"2024-12-01","conditions":"Gastroesophageal Reflux (GER), Infants","enrollment":60},{"nctId":"NCT00149149","phase":"PHASE1","title":"Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2005-05-01","conditions":"Healthy","enrollment":10},{"nctId":"NCT05549778","phase":"PHASE1, PHASE2","title":"Polaprezinc Treatment for Enzalutamide- or Abiraterone-resistant CRPC","status":"COMPLETED","sponsor":"Jiangnan University","startDate":"2021-01-06","conditions":"Castration-resistant Prostate Cancer","enrollment":12},{"nctId":"NCT05333315","phase":"NA","title":"Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults","status":"COMPLETED","sponsor":"University of Primorska","startDate":"2022-04-20","conditions":"Overweight and Obesity, Inflammation, Hypercholesterolemia","enrollment":120},{"nctId":"NCT04849182","phase":"NA","title":"Vertistop® D and Vertistop® L in Preventing Recurrence of High-recurrence BPPV","status":"COMPLETED","sponsor":"Azienda Sanitaria Locale di Matera","startDate":"2018-12-04","conditions":"Benign Paroxysmal Positional Vertigo (BPPV)","enrollment":128},{"nctId":"NCT04430998","phase":"PHASE3","title":"Efficacy of Zinc L-Carnosine Mouth Rinse","status":"UNKNOWN","sponsor":"University of Milan","startDate":"2020-06","conditions":"Periodontal Index, Pain","enrollment":75},{"nctId":"NCT03997188","phase":"PHASE3","title":"Zinc-L-Carnosine Prevents Dysphagia in Breast Cancer Patients Undergoing Adjuvant Radiotherapy","status":"COMPLETED","sponsor":"Cynthia Aristei","startDate":"2015-12-21","conditions":"Breast Cancer Female, Dysphagia, Adjuvant Radiotherapy","enrollment":40},{"nctId":"NCT02243618","phase":"NA","title":"The Effect of Proton Pump Inhibitor and Polaprezinc Combination Therapy for Healing of Endoscopic Submucosal Dissection-induced Ulcer","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2015-01-14","conditions":"Gastric Adenoma, Early Gastric Cancer","enrollment":153},{"nctId":"NCT03467438","phase":"PHASE4","title":"Efficacy of Zinc L-carnosine in Maintaining Remission of Gastroesophageal Reflux Disease","status":"UNKNOWN","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2018-11-22","conditions":"Gastroesophageal Reflux Disease","enrollment":80}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"ABDOMINAL PAIN UPPER"},{"count":2,"reaction":"EUGLYCAEMIC DIABETIC KETOACIDOSIS"},{"count":2,"reaction":"FALL"},{"count":2,"reaction":"HEPATOTOXICITY"},{"count":2,"reaction":"VOMITING"},{"count":1,"reaction":"ASTHENIA"},{"count":1,"reaction":"FREQUENT BOWEL MOVEMENTS"},{"count":1,"reaction":"GAIT DISTURBANCE"},{"count":1,"reaction":"GASTROINTESTINAL PAIN"},{"count":1,"reaction":"RIB FRACTURE"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Zinc-l-carnosine","genericName":"Zinc-l-carnosine","companyName":"Fondazione IRCCS Policlinico San Matteo di Pavia","companyId":"fondazione-irccs-policlinico-san-matteo-di-pavia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zinc-l-carnosine forms a chelate complex that protects and promotes healing of the gastrointestinal mucosa by reducing oxidative stress and enhancing mucosal defense mechanisms. Used for Gastric ulcer, Gastritis, Gastrointestinal mucosal damage and inflammation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}