{"id":"zinc","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Nausea"},{"rate":null,"effect":"Copper deficiency (with chronic high-dose use)"},{"rate":"5-15","effect":"Gastrointestinal upset"},{"rate":null,"effect":"Metallic taste"}]},"_chembl":{"chemblId":"CHEMBL3988900","moleculeType":"Small molecule","molecularWeight":"81.39"},"_dailymed":{"setId":"1f310fb1-185a-b467-e063-6294a90a72fe","title":"AXIS-Y COMPLETE NO-STRESS PHYSICAL SUNSCREEN V.3 (ZINC OXIDE) CREAM [ASIA MASTER TRADE CO.,LTD]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Zinc acts as a structural and catalytic component of over 300 enzymes involved in metabolism, immunity, and cell signaling. It is critical for T-cell development and function, antibody production, and wound healing. Zinc deficiency impairs immune response and delays tissue repair, while supplementation restores these functions in deficient populations.","oneSentence":"Zinc is an essential mineral cofactor that supports immune function, wound healing, and protein synthesis by activating numerous enzymes and transcription factors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:03.501Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Zinc deficiency supplementation"},{"name":"Common cold symptom reduction (when initiated early)"},{"name":"Wound healing support"},{"name":"Age-related macular degeneration (as part of AREDS formulation)"}]},"trialDetails":[{"nctId":"NCT05882149","phase":"NA","title":"Single Strain Probiotic","status":"COMPLETED","sponsor":"Rosa Sola","startDate":"2023-06-22","conditions":"Abdominal Obesity","enrollment":124},{"nctId":"NCT07488416","phase":"NA","title":"Clinical and Radiographic Outcomes of Lesion Sterilization and Tissue Repair Using Zinc Oxide/ 6-gingerol Mix Versus Triple Antibiotic Paste in Non-vital Primary Molars","status":"RECRUITING","sponsor":"Al-Azhar University","startDate":"2024-10-01","conditions":"Clinical Outcomes, Radiographic Outcomes, Lesion Sterilization","enrollment":60},{"nctId":"NCT07479004","phase":"NA","title":"Effect of Cream Paste Containg Pleuran on Selected Skin Dermatoses (Neonatal Pustulosis, Diaper Dermatitis, Perioral Dermatitis).","status":"COMPLETED","sponsor":"Pleuran, s.r.o.","startDate":"2024-05-01","conditions":"Diaper Dermatitis, Perioral Dermatitis, Neonatal Pustulosis","enrollment":110},{"nctId":"NCT06075134","phase":"NA","title":"EMG-guided Botox Injection Versus Conventional Botox Injection in Gummy Smile Patients","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-11-01","conditions":"Excessive Gingival Display","enrollment":32},{"nctId":"NCT04278768","phase":"PHASE1, PHASE2","title":"Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS)","status":"SUSPENDED","sponsor":"Curis, Inc.","startDate":"2020-07-06","conditions":"Acute Myelogenous Leukemia, Myelodysplastic Syndrome","enrollment":366},{"nctId":"NCT06430060","phase":"PHASE3","title":"Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-04-15","conditions":"Plaque, Dental, Gingivitis","enrollment":86},{"nctId":"NCT07475364","phase":"PHASE1, PHASE2","title":"Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis","status":"NOT_YET_RECRUITING","sponsor":"University of Faisalabad","startDate":"2026-05-01","conditions":"Pulp Necrosis","enrollment":180},{"nctId":"NCT05853692","phase":"NA","title":"Prevention of Oral Mucositis in Head and Neck Cancer.","status":"RECRUITING","sponsor":"Catholic University of the Sacred Heart","startDate":"2022-10-10","conditions":"Oral Mucositis","enrollment":130},{"nctId":"NCT06479226","phase":"PHASE3","title":"Effect of Mouthwash in Reducing the Symptoms Associated With Flu and Cold Viruses","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2022-06-05","conditions":"Healthy","enrollment":150},{"nctId":"NCT06517862","phase":"PHASE4","title":"Efficacy & Safety of Oral Adjuvants to Phototherapy in Neonatal Hyperbilirubinemia","status":"RECRUITING","sponsor":"Amira Adel Fouly","startDate":"2024-09-01","conditions":"Neonatal Hyperbilirubinemia","enrollment":80},{"nctId":"NCT07210138","phase":"PHASE3","title":"Clinical Investigation of PerioGard (Test) Regimen","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-08-18","conditions":"Gingivitis","enrollment":80},{"nctId":"NCT06551285","phase":"NA","title":"Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.","status":"RECRUITING","sponsor":"Celia Bañuls","startDate":"2024-02-01","conditions":"Polycystic Ovary Syndrome, Metabolic Syndrome","enrollment":120},{"nctId":"NCT07478497","phase":"NA","title":"30 Day Insulin Balance Metabolic Health Optimization Protocol","status":"RECRUITING","sponsor":"Efforia, Inc","startDate":"2025-10-21","conditions":"Insulin","enrollment":100},{"nctId":"NCT04874688","phase":"NA","title":"Child Health, Agriculture and Integrated Nutrition","status":"COMPLETED","sponsor":"Queen Mary University of London","startDate":"2021-04-26","conditions":"Stunting","enrollment":192},{"nctId":"NCT06260891","phase":"PHASE2","title":"Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-02-14","conditions":"Sickle Cell Disease","enrollment":34},{"nctId":"NCT06120140","phase":"PHASE2","title":"Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib","status":"RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2024-02-16","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":300},{"nctId":"NCT04884815","phase":"PHASE1, PHASE2","title":"A Phase 1/2/3 Study of UX701 Gene Therapy in Adults With Wilson Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ultragenyx Pharmaceutical Inc","startDate":"2021-09-27","conditions":"Wilson Disease","enrollment":82},{"nctId":"NCT07464002","phase":"NA","title":"Effects of Habitual Water Intake on Thirst in Healthy Young Adults Explained by Osmoadaptive Metabolism, Brain and Kidney Function (Adapt-Thirst)","status":"NOT_YET_RECRUITING","sponsor":"Jodi Stookey","startDate":"2026-05-01","conditions":"Chronic Underhydration, Thirst; Due to Deprivation of Water, Aestivation Metabolism","enrollment":120},{"nctId":"NCT06654089","phase":"PHASE4","title":"A Study Evaluating Quality of Life Parameters Following Use of Emergen-C","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-10-30","conditions":"Dietary Supplements","enrollment":299},{"nctId":"NCT02233764","phase":"NA","title":"Effect of Iron/Zinc-Biofortified Pearl Millet on Growth and Immunity in Children Aged 12-18 Months in India","status":"COMPLETED","sponsor":"Cornell University","startDate":"2017-05-08","conditions":"Iron Deficiency, Zinc Deficiency","enrollment":223},{"nctId":"NCT07140874","phase":"PHASE2","title":"Zinc as an Adjunctive Therapy for Cervical Dystonia","status":"RECRUITING","sponsor":"University of Florida","startDate":"2026-02-20","conditions":"Cervical Dystonia","enrollment":20},{"nctId":"NCT05057429","phase":"NA","title":"A Bioelectric Dressing for Post De-Roofing Treatment of HS","status":"COMPLETED","sponsor":"University of Miami","startDate":"2021-10-11","conditions":"Hidradenitis Suppurativa","enrollment":12},{"nctId":"NCT06979180","phase":"NA","title":"A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.","status":"RECRUITING","sponsor":"Papillex Inc.","startDate":"2026-03","conditions":"CIN - Cervical Intraepithelial Neoplasia, CIN 1, CIN 2","enrollment":60},{"nctId":"NCT07301216","phase":"","title":"Off Treatment Urinary Copper Excretion in Wilson Disease, Pilot Study","status":"RECRUITING","sponsor":"Yale University","startDate":"2026-01-08","conditions":"Wilson Disease","enrollment":30},{"nctId":"NCT05336682","phase":"NA","title":"Evaluation of Lesion Sterilization and Tissue Repair Techniques Versus Pulpectomy in Primary Molars With Inflammed Pulp","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-09-20","conditions":"Pulpitis - Irreversible","enrollment":66},{"nctId":"NCT07405554","phase":"PHASE2","title":"Zinc Supplementation With Botulinum Toxin for Overactive Bladder","status":"RECRUITING","sponsor":"Endeavor Health","startDate":"2026-02-26","conditions":"Overactive Bladder (OAB)","enrollment":72},{"nctId":"NCT07437794","phase":"NA","title":"Clinical and Radiographic Assessment of Neo Putty MTA Versus Formocresol Used in Vital Pulpotomy of Mandibular Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2026-03-01","conditions":"Deep Caries in Primary Molars","enrollment":68},{"nctId":"NCT07069166","phase":"NA","title":"Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes","status":"RECRUITING","sponsor":"University of Pavia","startDate":"2025-07-30","conditions":"Periodontitis, Type 2 Diabetes Mellitus (T2DM)","enrollment":40},{"nctId":"NCT06327529","phase":"NA","title":"Zinc and Iron Absorption From Common Beans in Young Adult Women","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2024-05-01","conditions":"Zinc Absorption, Iron Absorption","enrollment":15},{"nctId":"NCT07424053","phase":"NA","title":"Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques","status":"NOT_YET_RECRUITING","sponsor":"Al-Azhar University","startDate":"2026-04","conditions":"Primary Teeth Indicated for Pulp Therapy","enrollment":126},{"nctId":"NCT07069218","phase":"NA","title":"Hydroxyapatite Toothpastes and Enamel Remineralization:","status":"RECRUITING","sponsor":"University of Pavia","startDate":"2025-07-25","conditions":"Enamel Hypomineralization, Tooth Erosion","enrollment":40},{"nctId":"NCT07069127","phase":"NA","title":"Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients","status":"RECRUITING","sponsor":"University of Pavia","startDate":"2025-07-30","conditions":"Celiac Disease, Dentin Hypersensitivity, Tooth Demineralization","enrollment":40},{"nctId":"NCT07414173","phase":"PHASE4","title":"6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health","status":"RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-01-28","conditions":"Gingivitis, Dental Plaque Accumulation","enrollment":90},{"nctId":"NCT06271564","phase":"EARLY_PHASE1","title":"Effectiveness of Topical Magnetite Zinc Oxide Composite Nanoparticles in the Management of Oral Potentially Malignant Lesions","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-02-29","conditions":"Oral Potentially Malignant Lesions","enrollment":20},{"nctId":"NCT04966507","phase":"PHASE2","title":"Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2022-02-17","conditions":"Gonorrhea","enrollment":89},{"nctId":"NCT07059065","phase":"NA","title":"FIBERGRAFT Aeridyan Posterolateral Fusion Study","status":"RECRUITING","sponsor":"DePuy Synthes Products, Inc.","startDate":"2025-08-15","conditions":"Degenerative Spine Disease","enrollment":316},{"nctId":"NCT07398846","phase":"PHASE3","title":"Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.","status":"RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-01-26","conditions":"Plaque","enrollment":135},{"nctId":"NCT07398885","phase":"NA","title":"Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial","status":"COMPLETED","sponsor":"University Tunis El Manar","startDate":"2024-07-01","conditions":"System; Lupus Erythematosus","enrollment":59},{"nctId":"NCT07395401","phase":"NA","title":"Evaluation of Zinc Oxide Eugenol and Iodoform-Calcium Hydroxide as Filling Materials in Primary Molar Root Canals Prepared by Rotary and Manual Files","status":"RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2026-02-15","conditions":"Carious Primary Molars Indicated for Pulpectomy","enrollment":44},{"nctId":"NCT05236374","phase":"NA","title":"Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2022-10-01","conditions":"Zinc Deficiency, Inflammation, Metabolic Diseases","enrollment":20},{"nctId":"NCT07398378","phase":"PHASE3","title":"Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride Toothpaste","status":"NOT_YET_RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-01-28","conditions":"Oral Malodor","enrollment":80},{"nctId":"NCT06240481","phase":"PHASE3","title":"Clinical Research Study to Assess the Efficacy of Two Brushing Regimens","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-09-23","conditions":"Dental Plaque, Gingivitis","enrollment":90},{"nctId":"NCT07386925","phase":"NA","title":"Pelargonium Graveolens Essential Oil as a Pulpotomy Agent in Primary Teeth","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-02","conditions":"Pulpitis - Reversible, Pulpotomies on Primary Molars","enrollment":30},{"nctId":"NCT07383363","phase":"NA","title":"Comparison of Efficacy and Safety of Vita 6 Versus Zinc Along With Applied Behavioural Therapy","status":"RECRUITING","sponsor":"Muhammad Aamir Latif","startDate":"2025-09-23","conditions":"Autism Spectrum Disorder","enrollment":64},{"nctId":"NCT06412653","phase":"PHASE2","title":"Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in GNAO1 Associated Disorders","status":"COMPLETED","sponsor":"Children's University Hospital Cologne, Germany","startDate":"2024-08-02","conditions":"GNAO1, Dystonia, Epilepsy","enrollment":13},{"nctId":"NCT07380022","phase":"NA","title":"Acceptability, Adherence, and Impact on the Bioavailability of Iron and Zinc of the Dietary Supplements Goodphyte IB Defense and Goodphyte Immunity in Adults With Chronic Diseases.","status":"RECRUITING","sponsor":"University of Thessaly","startDate":"2025-07-09","conditions":"IBD, Hypertension (HTN), Multiple Sclerosis","enrollment":100},{"nctId":"NCT05340465","phase":"PHASE2","title":"Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants","status":"RECRUITING","sponsor":"University of Washington","startDate":"2022-11-27","conditions":"Prematurity, Iron-deficiency, Iron Deficiency Anemia","enrollment":120},{"nctId":"NCT07153549","phase":"NA","title":"Biolizin for Improving Functional Poor Appetite in Children Aged 6 to 36 Months (CTBE2502)","status":"RECRUITING","sponsor":"Haiphong University of Medicine and Pharmacy","startDate":"2025-09-20","conditions":"Feeding and Eating Disorders of Childhood, Appetite Disorders, Functional Poor Appetite","enrollment":110},{"nctId":"NCT07379645","phase":"NA","title":"A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes","status":"NOT_YET_RECRUITING","sponsor":"NutriScience Innovations, LLC","startDate":"2026-01-15","conditions":"Heartburn","enrollment":50},{"nctId":"NCT07367412","phase":"NA","title":"Zinc Supplementation and Infections in Older Medical Patients","status":"NOT_YET_RECRUITING","sponsor":"Herlev Hospital","startDate":"2026-02-01","conditions":"Older Adults (65 Years and Older), Medical Patients in the Emergency Department","enrollment":8000},{"nctId":"NCT06561061","phase":"PHASE2, PHASE3","title":"Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2)","status":"COMPLETED","sponsor":"Indiana University","startDate":"2025-02-10","conditions":"Sickle Cell Disease","enrollment":100},{"nctId":"NCT05074238","phase":"NA","title":"Influence of Sun Protection and Linear Repair of Cutaneous Surgical Defects","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, Davis","startDate":"2021-07-16","conditions":"Surgical Wound, Wound Heal, Wound of Skin","enrollment":50},{"nctId":"NCT07366229","phase":"PHASE2","title":"Topical Application of Engineered Lactobacillus Reuteri With a Zinc Sulfate-Tannic Acid MPN Coating for Acne","status":"NOT_YET_RECRUITING","sponsor":"Shenzhen People's Hospital","startDate":"2025-12-30","conditions":"Acne","enrollment":196},{"nctId":"NCT06602466","phase":"NA","title":"A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-09-23","conditions":"Dental Plaque, Gingivitis","enrollment":175},{"nctId":"NCT07169188","phase":"NA","title":"A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-09-09","conditions":"Dental Plaque, Gingivitis","enrollment":154},{"nctId":"NCT07352501","phase":"NA","title":"Effectiveness of Pulsed Electromagnetic Fields and Nutraceutical Supplementation in Women With Distal Radius Fracture","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Palermo","startDate":"2025-03-10","conditions":"Fracture of Distal Radius, Bone Fractures, Wrist Injuries","enrollment":100},{"nctId":"NCT07343804","phase":"NA","title":"THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE","status":"RECRUITING","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2025-11-01","conditions":"Cardiovascular Disease Risk Factor, Periapical Periodontitis","enrollment":80},{"nctId":"NCT06430359","phase":"","title":"Circadian Variation of Urinary Copper Excretion in Wilson Disease Patients","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2025-01-10","conditions":"Wilson Disease","enrollment":30},{"nctId":"NCT07263698","phase":"PHASE3","title":"Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash","status":"ACTIVE_NOT_RECRUITING","sponsor":"Colgate Palmolive","startDate":"2025-12-01","conditions":"Gingivitis, Plaque, Dental","enrollment":80},{"nctId":"NCT07341217","phase":"NA","title":"Chemo Brain Prehab Project","status":"NOT_YET_RECRUITING","sponsor":"Dr. Chris Gaffney","startDate":"2026-01-30","conditions":"Colorectal Cancer, Older Adults (60 - 85 Years Old), Physically Inactive","enrollment":86},{"nctId":"NCT07271316","phase":"PHASE2","title":"Alii Supplement Study","status":"RECRUITING","sponsor":"Texas Christian University","startDate":"2026-01-12","conditions":"Nutrient Deficiency, Happiness, Digestive Health","enrollment":68},{"nctId":"NCT07100977","phase":"NA","title":"A Clinical Trial to Investigate the Acute Effect of Bragg Apple Cider Vinegar Supplement on Blood Glucose Control in a Healthy Adult Population","status":"NOT_YET_RECRUITING","sponsor":"Bragg Live Food Products","startDate":"2026-01","conditions":"Postprandial Glucose, Blood Glucose Concentration","enrollment":24},{"nctId":"NCT06487533","phase":"","title":"Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder","status":"RECRUITING","sponsor":"Spark Biomedical, Inc.","startDate":"2025-02-19","conditions":"Opioid Withdrawal, Opioid Use Disorder","enrollment":20},{"nctId":"NCT07311070","phase":"PHASE3","title":"Treatment of Basal Cell Carcinoma (BCC) of the Skin, of the Morpheiform, Infiltrative, and Noduloulcerative Types in Inoperable Patients and Not Suitable for Radiotherapy Using Formulated Methylene Blue","status":"ENROLLING_BY_INVITATION","sponsor":"Daryoush Hamidi Alamdari, PhD","startDate":"2025-10-21","conditions":"Advanced Basal Cell Carcinoma (BCC), Inoperable Disease, Morpheaform Basal Cell Carcinoma","enrollment":20},{"nctId":"NCT07311057","phase":"PHASE3","title":"Investigation of Effect of Formulated Methylene Blue on Treatment of Squamous Cell Carcinoma Skin Cancer in Inoperable Patients and Not Suitable for Radiotherapy","status":"ENROLLING_BY_INVITATION","sponsor":"Daryoush Hamidi Alamdari, PhD","startDate":"2025-12-20","conditions":"SCC - Squamous Cell Carcinoma, SCC - Squamous Cell Carcinoma of Skin, Inoperable Disease","enrollment":20},{"nctId":"NCT06564181","phase":"","title":"The Relation Between Serum Zinc and Lupus Nephritis","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-10","conditions":"Lupus Nephritis","enrollment":75},{"nctId":"NCT07313254","phase":"NA","title":"Clinical And Radiographic Evaluation Of Zinc Substituted Nanohyrdoxyappatite Bone Graft And Advanced Platelet Rich Fibrin Block In The Treatment Of Periodontal Intrabony Defects","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2023-01-15","conditions":"Periodontitis, Periodontal Diseases","enrollment":30},{"nctId":"NCT07022938","phase":"PHASE4","title":"Nutritional Supplement for Treating Chemotherapy Induced Neuropathy","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2021-11-01","conditions":"Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy","enrollment":71},{"nctId":"NCT06293521","phase":"PHASE2","title":"Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01-01","conditions":"Deep Caries","enrollment":40},{"nctId":"NCT07275827","phase":"PHASE3","title":"Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-02-01","conditions":"HELICOBACTER PYLORI INFECTIONS","enrollment":88},{"nctId":"NCT06770374","phase":"NA","title":"Effectiveness of a Zinc Oxide Adhesive Securement Device in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients","status":"RECRUITING","sponsor":"Hospital Arnau de Vilanova","startDate":"2025-02-01","conditions":"Vascular Access Complication, Skin and Subcutaneous Tissue Disorders, Phlebitis","enrollment":400},{"nctId":"NCT06783088","phase":"","title":"Quantification With Lutetium-177 on Cadmium-Zinc-Telluride Camera 3D","status":"COMPLETED","sponsor":"Central Hospital, Nancy, France","startDate":"2025-03-10","conditions":"Prostate Cancer","enrollment":20},{"nctId":"NCT07284095","phase":"NA","title":"Nutritional Intervention With Tenebrio Molitor Powder in Children With Chronic Malnutrition in the Democratic Republic of the Congo","status":"NOT_YET_RECRUITING","sponsor":"Clinica Universidad de Navarra, Universidad de Navarra","startDate":"2026-02-01","conditions":"Chronic Malnutrition, Stunting of Growth","enrollment":40},{"nctId":"NCT07265115","phase":"NA","title":"Preventive Nutritional Supplements for Preclinical Pathologies","status":"COMPLETED","sponsor":"Centro de Edafología y Biología Aplicada del Segura","startDate":"2025-06-02","conditions":"Prediabetes","enrollment":21},{"nctId":"NCT06102044","phase":"PHASE3","title":"Zinc Supplementation for Young Infants With Clinical Severe Infection in Tanzania","status":"RECRUITING","sponsor":"Harvard School of Public Health (HSPH)","startDate":"2024-12-27","conditions":"Neonatal Infection","enrollment":3250},{"nctId":"NCT07073781","phase":"NA","title":"Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation","status":"RECRUITING","sponsor":"Leeds Beckett University","startDate":"2025-08-15","conditions":"Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes), Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)","enrollment":70},{"nctId":"NCT07270042","phase":"NA","title":"Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection","status":"NOT_YET_RECRUITING","sponsor":"Tishreen University","startDate":"2025-12-01","conditions":"Hyperactive Masseter Muscle","enrollment":20},{"nctId":"NCT04837703","phase":"","title":"MAP to Provide Access to Eltrombopag, for Treatment of Patients With Medically Significant Thrombocytopenia","status":"AVAILABLE","sponsor":"Novartis Pharmaceuticals","startDate":"","conditions":"Thrombocytopenia","enrollment":""},{"nctId":"NCT07265089","phase":"NA","title":"Zinc Oxide-Ozonated Olive Oil vs Metapex in Primary Anterior Teeth","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-12-01","conditions":"Carious Anterior Teeth","enrollment":52},{"nctId":"NCT07170904","phase":"","title":"Dietary Patterns, Inflammation, Zinc Status, and Body Composition in Multi-Ethnic Women of Reproductive Age in Jakarta","status":"RECRUITING","sponsor":"Indonesia University","startDate":"2025-02-03","conditions":"Body Composition, Zinc Status, Dietary Analysis","enrollment":188},{"nctId":"NCT07263802","phase":"NA","title":"Effect of a Food Supplement on Glycemic Parameters in Patients With Impaired Glucose Metabolism","status":"NOT_YET_RECRUITING","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2025-12-01","conditions":"Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)","enrollment":90},{"nctId":"NCT04935840","phase":"NA","title":"Evaluation of the Effect of FertyBiotic Pregnancy in the Metabolic Profile in Pregnant Women","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fertypharm","startDate":"2021-05-05","conditions":"Pregnancy Related","enrollment":84},{"nctId":"NCT02950259","phase":"PHASE1","title":"Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)","status":"COMPLETED","sponsor":"Providence Health & Services","startDate":"2017-02-09","conditions":"Breast Neoplasm, Breast Neoplasm, Male, Triple Negative Breast Cancer","enrollment":16},{"nctId":"NCT06770114","phase":"PHASE3","title":"Clinical Study to Investigate a New Mouthwash in Reducing Plaque and Helping Prevent Gum Problems on Dental Implants Over a 6-month Period of Product Use","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2021-10-18","conditions":"Gingivitis","enrollment":80},{"nctId":"NCT07240246","phase":"NA","title":"Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults","status":"RECRUITING","sponsor":"FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & Innovation","startDate":"2025-10-24","conditions":"GLP-1, Obesity &Amp; Overweight, Dietary Supplement","enrollment":40},{"nctId":"NCT03558464","phase":"NA","title":"Effectiveness Study During the First 1,000 Days in Kenya","status":"COMPLETED","sponsor":"Fabian Rohner","startDate":"2018-06-08","conditions":"Stunting, Anemia, Micronutrient Deficiency","enrollment":1199},{"nctId":"NCT06567717","phase":"PHASE2","title":"Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis","status":"RECRUITING","sponsor":"Cedars-Sinai Medical Center","startDate":"2025-11-03","conditions":"Idiopathic Pulmonary Fibrosis","enrollment":60},{"nctId":"NCT05783687","phase":"","title":"Real World Evidence Study in Subjects With Wilson's Disease","status":"COMPLETED","sponsor":"Orphalan","startDate":"2023-06-28","conditions":"Wilson Disease","enrollment":50},{"nctId":"NCT03819088","phase":"NA","title":"Effects on Quality of Life With Zinc Supplementation in Patients With Gastrointestinal Cancer","status":"COMPLETED","sponsor":"Emory University","startDate":"2019-04-17","conditions":"Gastric Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Unresectable Esophageal Carcinoma","enrollment":17},{"nctId":"NCT02500849","phase":"PHASE1","title":"Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2016-03-10","conditions":"HIV","enrollment":12},{"nctId":"NCT07210164","phase":"NA","title":"Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study","status":"RECRUITING","sponsor":"Aristotle University Of Thessaloniki","startDate":"2025-12-01","conditions":"ERAS, Compliance, Quality of Life (QOL)","enrollment":100},{"nctId":"NCT05990166","phase":"PHASE2","title":"Assessing the Effect of a Mineral-enriched Powder on Iron Deficiency in Women of Reproductive Age","status":"ACTIVE_NOT_RECRUITING","sponsor":"Carleton University","startDate":"2023-04-27","conditions":"Iron Deficiency, Iron Deficiency Anaemia","enrollment":150},{"nctId":"NCT06137833","phase":"NA","title":"Wide Spectrum Micronutrients Supplementation in Patients With Cancer Related Fatigue During Neoadjuvant and Adjuvant Chemotherapy","status":"RECRUITING","sponsor":"Pharmanutra S.p.a.","startDate":"2023-11-27","conditions":"Fatigue, Breast Cancer","enrollment":92},{"nctId":"NCT06081114","phase":"NA","title":"Micronutrient Dose Response Study in Bangladesh","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2023-10-22","conditions":"Micronutrient Status","enrollment":643},{"nctId":"NCT07193849","phase":"PHASE4","title":"Zinc Oxide VS MEBO","status":"RECRUITING","sponsor":"King Abdullah Medical City","startDate":"2023-12-31","conditions":"Pressure Injury, Pressure Injury Stage 2, Bedsore","enrollment":76},{"nctId":"NCT07187609","phase":"NA","title":"Zinc Incorporated Bovine Derived- Hydroxyappatite Xenograft in Immediately Placed Implant","status":"RECRUITING","sponsor":"Suez Canal University","startDate":"2025-08-13","conditions":"Implant, Zinc Status","enrollment":16},{"nctId":"NCT07186907","phase":"NA","title":"Hydrocolloid Dressings in Diaper Dermatitis","status":"COMPLETED","sponsor":"Gozde AKSUCU","startDate":"2017-11-13","conditions":"Diaper Dermatitis, Diaper Dermatitis Healing, Diaper Rash","enrollment":44},{"nctId":"NCT07167732","phase":"","title":"CTNNB1 Neurodevelopmental Syndrome - Natural History Study","status":"RECRUITING","sponsor":"University Medical Centre Ljubljana","startDate":"2024-06-14","conditions":"CTNNB1 Neurodevelopmental Syndrome","enrollment":250},{"nctId":"NCT07180329","phase":"NA","title":"Zinc and Selenium Bioactivity","status":"COMPLETED","sponsor":"University of Lahore","startDate":"2023-02-01","conditions":"Immunomodulatory Drugs, Tuberculosis","enrollment":90},{"nctId":"NCT05926947","phase":"NA","title":"OXXYNEA® GS: Study for Glycaemia Management","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fytexia","startDate":"2023-07-05","conditions":"Prediabetic State, Overweight","enrollment":87}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[{"date":"20030214","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"20030214","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19960829","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"20240425","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"20140612","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"20010216","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19860626","type":"ORIG","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19990831","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19990122","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19970117","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19870629","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"19860909","type":"SUPPL","sponsor":"HOSPIRA","applicationNumber":"NDA018959"},{"date":"20241028","type":"SUPPL","sponsor":"APOTEX","applicationNumber":"ANDA218059"},{"date":"20240610","type":"ORIG","sponsor":"APOTEX","applicationNumber":"ANDA218059"},{"date":"20130321","type":"SUPPL","sponsor":"HAMELN PHARMA PLUS","applicationNumber":"NDA021751"},{"date":"20050804","type":"SUPPL","sponsor":"HAMELN PHARMA PLUS","applicationNumber":"NDA021751"},{"date":"20040811","type":"ORIG","sponsor":"HAMELN PHARMA PLUS","applicationNumber":"NDA021751"},{"date":"20210521","type":"ORIG","sponsor":"EXELA PHARMA","applicationNumber":"ANDA212007"},{"date":"20240717","type":"ORIG","sponsor":"SOMERSET THERAPS LLC","applicationNumber":"ANDA216135"}],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["zinc sulfate","Zinc Picolinate 50 mg","Placebo","Standard treatment","WILZIN 25mg"],"phase":"marketed","status":"active","brandName":"Zinc","genericName":"Zinc","companyName":"University of Iowa","companyId":"university-of-iowa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zinc is an essential mineral cofactor that supports immune function, wound healing, and protein synthesis by activating numerous enzymes and transcription factors. Used for Zinc deficiency supplementation, Common cold symptom reduction (when initiated early), Wound healing support.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"AU","regulator":"TGA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"CH","regulator":"Swissmedic","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"NO","regulator":"NoMA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"IS","regulator":"IMA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"NZ","regulator":"Medsafe","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"AT","regulator":"AGES","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"BE","regulator":"FAMHP","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"EU","regulator":"EMA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":"EMEA/H/C/000535"},{"country_code":"GB","regulator":"MHRA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"BG","regulator":"BDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"HR","regulator":"HALMED","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"CY","regulator":"PHS","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"CZ","regulator":"SUKL","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"DK","regulator":"DKMA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"EE","regulator":"SAM","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"FI","regulator":"Fimea","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"FR","regulator":"ANSM","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"DE","regulator":"BfArM","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"GR","regulator":"EOF","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"HU","regulator":"OGYEI","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"IE","regulator":"HPRA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"IT","regulator":"AIFA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"LV","regulator":"ZVA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"LT","regulator":"VVKT","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"LU","regulator":"MS","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"MT","regulator":"MMA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"NL","regulator":"MEB","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"PL","regulator":"URPL","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"PT","regulator":"Infarmed","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"RO","regulator":"ANMDMR","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"SK","regulator":"SIDC","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"SI","regulator":"JAZMP","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"ES","regulator":"AEMPS","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null},{"country_code":"SE","regulator":"MPA","status":"approved","approval_date":null,"mah":null,"brand_name_local":"Wilzin","application_number":null}],"trialStats":{"total":21,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}