{"id":"zilpaterol","rwe":[{"pmid":"41554531","year":"2026","title":"Veterinary Drug Residues in Animal-Origin Food: a UPLC-MS/MS Screening Method for the Determination of 21 Beta-Agonists in Animal Lung and Liver According to Commission Implementing Regulation (EU) 2021/808.","finding":"","journal":"Journal of mass spectrometry : JMS","studyType":"Clinical Study"},{"pmid":"41535188","year":"2026","title":"Implementation and Benefits of Beta-Agonists in Beef Production.","finding":"","journal":"The Veterinary clinics of North America. Food animal practice","studyType":"Clinical Study"},{"pmid":"41530016","year":"2026","title":"Introduction to Beta Agonists.","finding":"","journal":"The Veterinary clinics of North America. Food animal practice","studyType":"Clinical Study"},{"pmid":"40808557","year":"2025","title":"Effects of zilpaterol hydrochloride and virginiamycin on growth performance, carcass characteristics, and visceral organ mass in feedlot lambs.","finding":"","journal":"Animal bioscience","studyType":"Clinical Study"},{"pmid":"40564244","year":"2025","title":"Effect of Guanidinoacetic Acid and Zilpaterol Hydrochloride Feed Additions on Lambs' Productive Performance, Carcass Characteristics, and Blood Chemistry.","finding":"","journal":"Animals : an open access journal from MDPI","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Beta-2 adrenergic receptor","category":"target"},{"label":"ADRB2","category":"gene"},{"label":"OPRM1","category":"gene"},{"label":"Active","category":"status"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["zilpaterol","RU-42173","zilpaterol hydrochloride"],"offLabel":[],"synonyms":["zilpaterol","RU-42173","zilpaterol hydrochloride"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"ecosystem":[],"mechanism":{"target":"Beta-2 adrenergic receptor, Mu-type opioid receptor","novelty":"First-in-class","targets":[{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"},{"gene":"OPRM1","source":"DrugCentral","target":"Mu-type opioid receptor","protein":"Mu-type opioid receptor"}],"modality":"Small Molecule","explanation":"Think of it like a key that unlocks a door in your muscle cells. When zilpaterol binds to the beta-2 adrenergic receptor, it sends a signal that tells the muscle cells to build more protein, which can help them grow stronger. This process is similar to how your body naturally responds to exercise, but zilpaterol can enhance this effect.","oneSentence":"Zilpaterol works by activating the beta-2 adrenergic receptor, which stimulates muscle protein synthesis and growth.","technicalDetail":"Zilpaterol acts as a partial agonist at the beta-2 adrenergic receptor, stimulating G-protein coupled signaling pathways that ultimately lead to increased protein synthesis and muscle growth through the activation of the mTOR pathway."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5645","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ZILPATEROL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:15:51.349806","biosimilars":[],"competitors":[{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"arformoterol","drugSlug":"arformoterol","fdaApproval":"2006-10-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bitolterol","drugSlug":"bitolterol","fdaApproval":"1984-12-28","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"bretylium","drugSlug":"bretylium","fdaApproval":"1986-03-06","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"brexpiprazole","drugSlug":"brexpiprazole","fdaApproval":"2015-07-10","patentExpiry":"Oct 12, 2032","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"zilpaterol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-target"},{"drugId":"arformoterol","brandName":"arformoterol","genericName":"arformoterol","approvalYear":"2006","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-target"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-target"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-target"},{"drugId":"bitolterol","brandName":"bitolterol","genericName":"bitolterol","approvalYear":"1984","relationship":"same-target"},{"drugId":"bretylium","brandName":"bretylium","genericName":"bretylium","approvalYear":"1986","relationship":"same-target"},{"drugId":"brexpiprazole","brandName":"brexpiprazole","genericName":"brexpiprazole","approvalYear":"2015","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"S384A1Y12J","INN_ID":"6349","RXNORM":"1727537","UMLSCUI":"C1259819","ChEMBL_ID":"CHEMBL462313","KEGG_DRUG":"","DRUGBANK_ID":"DB11479","PUBCHEM_CID":"3086576","SECONDARY_CAS_RN":"119520-06-8","MESH_SUPPLEMENTAL_RECORD_UI":"C475840"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":185,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41554531","title":"Veterinary Drug Residues in Animal-Origin Food: a UPLC-MS/MS Screening Method for the Determination of 21 Beta-Agonists in Animal Lung and Liver According to Commission Implementing Regulation (EU) 2021/808.","journal":"Journal of mass spectrometry : JMS"},{"date":"2026 Mar","pmid":"41535188","title":"Implementation and Benefits of Beta-Agonists in Beef Production.","journal":"The Veterinary clinics of North America. Food animal practice"},{"date":"2026 Mar","pmid":"41530016","title":"Introduction to Beta Agonists.","journal":"The Veterinary clinics of North America. Food animal practice"},{"date":"2025 Nov","pmid":"40808557","title":"Effects of zilpaterol hydrochloride and virginiamycin on growth performance, carcass characteristics, and visceral organ mass in feedlot lambs.","journal":"Animal bioscience"},{"date":"2025 Jun 7","pmid":"40564244","title":"Effect of Guanidinoacetic Acid and Zilpaterol Hydrochloride Feed Additions on Lambs' Productive Performance, Carcass Characteristics, and Blood Chemistry.","journal":"Animals : an open access journal from MDPI"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ZILPATEROL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zilpaterol is a small molecule modality targeting the beta-2 adrenergic receptor. Its mechanism of action involves activating this receptor, leading to increased muscle protein synthesis and growth. However, its commercial status and approved indications are unknown. Further research is needed to determine its efficacy and safety profile. As a result, it is not currently available for clinical use.","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"enriching","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}