{"id":"zaldiar","safety":{"commonSideEffects":[{"rate":"15–25%","effect":"Nausea"},{"rate":"10–20%","effect":"Dizziness"},{"rate":"10–15%","effect":"Constipation"},{"rate":"5–10%","effect":"Headache"},{"rate":"5–10%","effect":"Somnolence"},{"rate":"5–10%","effect":"Vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tramadol acts as a weak μ-opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, enhancing descending pain inhibitory pathways. Paracetamol works through poorly understood mechanisms involving central COX inhibition and endocannabinoid system modulation. The combination provides synergistic pain relief for moderate pain.","oneSentence":"Zaldiar combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with paracetamol (acetaminophen) to provide analgesia through dual pathways.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:39:41.735Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate acute pain"},{"name":"Moderate chronic pain"}]},"trialDetails":[{"nctId":"NCT00973232","phase":"PHASE1","title":"A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers","status":"COMPLETED","sponsor":"Labopharm Inc.","startDate":"2008-05","conditions":"Healthy","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Oral Zaldiar"],"phase":"marketed","status":"active","brandName":"Zaldiar®","genericName":"Zaldiar®","companyName":"Labopharm Inc.","companyId":"labopharm-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zaldiar combines tramadol (an opioid agonist and monoamine reuptake inhibitor) with paracetamol (acetaminophen) to provide analgesia through dual pathways. Used for Moderate acute pain, Moderate chronic pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}