{"id":"za","safety":{"commonSideEffects":[{"rate":null,"effect":"Osteonecrosis of the jaw"},{"rate":null,"effect":"Renal impairment"},{"rate":null,"effect":"Hypocalcemia"},{"rate":"30-40","effect":"Fever"},{"rate":"20-30","effect":"Myalgia/arthralgia"},{"rate":"20-30","effect":"Nausea"}]},"_chembl":null,"_dailymed":{"setId":"baba507f-6557-4551-815c-9ab6606e4ee1","title":"ZAFIRLUKAST TABLET, COATED [STRIDES PHARMA SCIENCE LIMITED]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bisphosphonates like zoledronic acid (ZA) bind to hydroxyapatite in bone and are internalized by osteoclasts during bone resorption. Once inside osteoclasts, they inhibit farnesyl pyrophosphate synthase in the mevalonate pathway, disrupting the prenylation of small GTPases essential for osteoclast function and survival. This leads to osteoclast apoptosis and reduced bone turnover.","oneSentence":"ZA is a bisphosphonate that inhibits bone resorption by suppressing osteoclast activity and promoting osteoclast apoptosis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:58:45.494Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multiple myeloma with bone disease"},{"name":"Metastatic bone disease in solid tumors"},{"name":"Hypercalcemia of malignancy"},{"name":"Osteoporosis"}]},"trialDetails":[{"nctId":"NCT07318298","phase":"NA","title":"Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets","status":"RECRUITING","sponsor":"Jordan University of Science and Technology","startDate":"2024-08-01","conditions":"The Application of Hyaluronic Acid on Teeth Bone Healing. 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