{"id":"z-officinale-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Heartburn"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ginger extract contains active compounds (gingerols and shogaols) that inhibit cyclooxygenase and 5-lipoxygenase enzymes, reducing inflammatory mediator production. It also possesses antioxidant properties that neutralize reactive oxygen species, contributing to its anti-inflammatory and gastroprotective effects.","oneSentence":"Zingiber officinale (ginger) extract exerts anti-inflammatory and antioxidant effects through inhibition of prostaglandin and leukotriene synthesis and free radical scavenging.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:45.713Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nausea and vomiting"},{"name":"Dyspepsia and gastrointestinal discomfort"},{"name":"Inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT06787222","phase":"PHASE2, PHASE3","title":"Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hasanuddin University","startDate":"2024-11-03","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT03755596","phase":"PHASE4","title":"Clinical Evaluation of the Use of Ginger Extract in the Management of Motion Sickness","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2019-01-02","conditions":"Motion Sickness","enrollment":184},{"nctId":"NCT03061916","phase":"PHASE3","title":"Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2017-03","conditions":"Dental Caries","enrollment":21}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":23,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Z. officinale extract","genericName":"Z. officinale extract","companyName":"Fundação Educacional Serra dos Órgãos","companyId":"funda-o-educacional-serra-dos-rg-os","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zingiber officinale (ginger) extract exerts anti-inflammatory and antioxidant effects through inhibition of prostaglandin and leukotriene synthesis and free radical scavenging. Used for Nausea and vomiting, Dyspepsia and gastrointestinal discomfort, Inflammatory conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}